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Central Positional Nystagmus: A Systematic Literature Review
OBJECTIVE: To provide a systematic review of the clinical and radiological features of lesion-induced central positional nystagmus (CPN) and identify salient characteristics that differentiate central from peripheral positional nystagmus (PN). METHODS: Systematic literature search according to the p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397512/ https://www.ncbi.nlm.nih.gov/pubmed/28473800 http://dx.doi.org/10.3389/fneur.2017.00141 |
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author | Macdonald, Nora K. Kaski, Diego Saman, Yougan Al-Shaikh Sulaiman, Amal Anwer, Amal Bamiou, Doris-Eva |
author_facet | Macdonald, Nora K. Kaski, Diego Saman, Yougan Al-Shaikh Sulaiman, Amal Anwer, Amal Bamiou, Doris-Eva |
author_sort | Macdonald, Nora K. |
collection | PubMed |
description | OBJECTIVE: To provide a systematic review of the clinical and radiological features of lesion-induced central positional nystagmus (CPN) and identify salient characteristics that differentiate central from peripheral positional nystagmus (PN). METHODS: Systematic literature search according to the preferred reporting items for systematic reviews and meta-analysis. RESULTS: A total of 82 patients from 28 studies met the participants intervention, comparison, outcomes, and study designs criteria for inclusion. An atypical direction of nystagmus for the stimulated canal was reported in 97.5% patients during Dix–Hallpike (D–H) and 54.5% upon supine roll testing. Five types of CPNs were identified during positional testing: positional horizontal nystagmus (pHN) (36.8%), positional downbeating nystagmus (pDBN) (29.2%), positional torsional nystagmus (pTN) (2.1%), positional upbeating nystagmus (pUBN) (2.1%), and a combination of the four profiles (29.9%). CPN was paroxysmal (<60 s) in 85% patients on straight head hanging (SHH), 63.9% on D–H, and 37.5% on supine roll, and had a latency <3 s upon positioning in 94.7% patients in which it was reported. Concurrent vertigo was reportedly present in 63.4% patients and 48.8% demonstrated other neurological signs. Radiologically, in 74.4%, there was mention of cerebellar involvement, isolated brainstem involvement in 8.5%, and 14.6% involved the fourth ventricle. CONCLUSION: Currently, there is a lack of robust data on the clinical and radiological characteristics of CPN highlighting the need for better phenotyping of CPN to help differentiate this entity from peripheral causes of PN. With increased awareness of CPN, particularly in the acute setting, we may see a change in the estimated prevalence of CPN and improved clinical markers to promptly identify the frequently sinister underlying causes. |
format | Online Article Text |
id | pubmed-5397512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53975122017-05-04 Central Positional Nystagmus: A Systematic Literature Review Macdonald, Nora K. Kaski, Diego Saman, Yougan Al-Shaikh Sulaiman, Amal Anwer, Amal Bamiou, Doris-Eva Front Neurol Neuroscience OBJECTIVE: To provide a systematic review of the clinical and radiological features of lesion-induced central positional nystagmus (CPN) and identify salient characteristics that differentiate central from peripheral positional nystagmus (PN). METHODS: Systematic literature search according to the preferred reporting items for systematic reviews and meta-analysis. RESULTS: A total of 82 patients from 28 studies met the participants intervention, comparison, outcomes, and study designs criteria for inclusion. An atypical direction of nystagmus for the stimulated canal was reported in 97.5% patients during Dix–Hallpike (D–H) and 54.5% upon supine roll testing. Five types of CPNs were identified during positional testing: positional horizontal nystagmus (pHN) (36.8%), positional downbeating nystagmus (pDBN) (29.2%), positional torsional nystagmus (pTN) (2.1%), positional upbeating nystagmus (pUBN) (2.1%), and a combination of the four profiles (29.9%). CPN was paroxysmal (<60 s) in 85% patients on straight head hanging (SHH), 63.9% on D–H, and 37.5% on supine roll, and had a latency <3 s upon positioning in 94.7% patients in which it was reported. Concurrent vertigo was reportedly present in 63.4% patients and 48.8% demonstrated other neurological signs. Radiologically, in 74.4%, there was mention of cerebellar involvement, isolated brainstem involvement in 8.5%, and 14.6% involved the fourth ventricle. CONCLUSION: Currently, there is a lack of robust data on the clinical and radiological characteristics of CPN highlighting the need for better phenotyping of CPN to help differentiate this entity from peripheral causes of PN. With increased awareness of CPN, particularly in the acute setting, we may see a change in the estimated prevalence of CPN and improved clinical markers to promptly identify the frequently sinister underlying causes. Frontiers Media S.A. 2017-04-20 /pmc/articles/PMC5397512/ /pubmed/28473800 http://dx.doi.org/10.3389/fneur.2017.00141 Text en Copyright © 2017 Macdonald, Kaski, Saman, Al-Shaikh Sulaiman, Anwer and Bamiou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Macdonald, Nora K. Kaski, Diego Saman, Yougan Al-Shaikh Sulaiman, Amal Anwer, Amal Bamiou, Doris-Eva Central Positional Nystagmus: A Systematic Literature Review |
title | Central Positional Nystagmus: A Systematic Literature Review |
title_full | Central Positional Nystagmus: A Systematic Literature Review |
title_fullStr | Central Positional Nystagmus: A Systematic Literature Review |
title_full_unstemmed | Central Positional Nystagmus: A Systematic Literature Review |
title_short | Central Positional Nystagmus: A Systematic Literature Review |
title_sort | central positional nystagmus: a systematic literature review |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397512/ https://www.ncbi.nlm.nih.gov/pubmed/28473800 http://dx.doi.org/10.3389/fneur.2017.00141 |
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