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Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder

Few studies have explored the neurobiological basis of insight level in obsessive-compulsive disorder (OCD), though the salience network (SN) has been implicated in insight deficits in schizophrenia. This study was then designed to investigate whether resting-state (rs) functional connectivity (FC)...

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Autores principales: Fan, Jie, Zhong, Mingtian, Zhu, Xiongzhao, Gan, Jun, Liu, Wanting, Niu, Chaoyang, Liao, Haiyan, Zhang, Hongchun, Yi, Jinyao, Tan, Changlian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397581/
https://www.ncbi.nlm.nih.gov/pubmed/28458998
http://dx.doi.org/10.1016/j.nicl.2017.04.002
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author Fan, Jie
Zhong, Mingtian
Zhu, Xiongzhao
Gan, Jun
Liu, Wanting
Niu, Chaoyang
Liao, Haiyan
Zhang, Hongchun
Yi, Jinyao
Tan, Changlian
author_facet Fan, Jie
Zhong, Mingtian
Zhu, Xiongzhao
Gan, Jun
Liu, Wanting
Niu, Chaoyang
Liao, Haiyan
Zhang, Hongchun
Yi, Jinyao
Tan, Changlian
author_sort Fan, Jie
collection PubMed
description Few studies have explored the neurobiological basis of insight level in obsessive-compulsive disorder (OCD), though the salience network (SN) has been implicated in insight deficits in schizophrenia. This study was then designed to investigate whether resting-state (rs) functional connectivity (FC) of SN was associated with insight level in OCD patients. We analyzed rs-functional magnetic resonance imaging (fMRI) data from 21 OCD patients with good insight (OCD-GI), 19 OCD patients with poor insight (OCD-PI), and 24 healthy controls (HCs). Seed-based whole-brain FC and ROI (region of interest)-wise connectivity analyses were performed with seeds/ROIs in the bilateral anterior insula (AI) and dorsal anterior cingulate cortex (dACC). The right AI-right medial orbital frontal cortex (mOFC) connectivity was found to be uniquely decreased in the OCD-PI group, and the value of this aberrant connectivity correlated with insight level in OCD patients. In addition, we found that the OCD-GI group had significantly increased right AI-left dACC connectivity within the SN, relative to HCs (overall trend for groups: OCD-GI > OCD-PI > HC). Our findings suggest that abnormal right AI-right mOFC FC may mediate insight deficits in OCD, perhaps due to impaired encoding and integration of self-evaluative information about OCD-related beliefs and behaviors. Our findings indicate a SN connectivity dissociation between OCD-GI and OCD-PI patients and support the notion of considering OCD-GI and OCD-PI as two distinct disorder subtypes.
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spelling pubmed-53975812017-04-28 Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder Fan, Jie Zhong, Mingtian Zhu, Xiongzhao Gan, Jun Liu, Wanting Niu, Chaoyang Liao, Haiyan Zhang, Hongchun Yi, Jinyao Tan, Changlian Neuroimage Clin Regular Article Few studies have explored the neurobiological basis of insight level in obsessive-compulsive disorder (OCD), though the salience network (SN) has been implicated in insight deficits in schizophrenia. This study was then designed to investigate whether resting-state (rs) functional connectivity (FC) of SN was associated with insight level in OCD patients. We analyzed rs-functional magnetic resonance imaging (fMRI) data from 21 OCD patients with good insight (OCD-GI), 19 OCD patients with poor insight (OCD-PI), and 24 healthy controls (HCs). Seed-based whole-brain FC and ROI (region of interest)-wise connectivity analyses were performed with seeds/ROIs in the bilateral anterior insula (AI) and dorsal anterior cingulate cortex (dACC). The right AI-right medial orbital frontal cortex (mOFC) connectivity was found to be uniquely decreased in the OCD-PI group, and the value of this aberrant connectivity correlated with insight level in OCD patients. In addition, we found that the OCD-GI group had significantly increased right AI-left dACC connectivity within the SN, relative to HCs (overall trend for groups: OCD-GI > OCD-PI > HC). Our findings suggest that abnormal right AI-right mOFC FC may mediate insight deficits in OCD, perhaps due to impaired encoding and integration of self-evaluative information about OCD-related beliefs and behaviors. Our findings indicate a SN connectivity dissociation between OCD-GI and OCD-PI patients and support the notion of considering OCD-GI and OCD-PI as two distinct disorder subtypes. Elsevier 2017-04-06 /pmc/articles/PMC5397581/ /pubmed/28458998 http://dx.doi.org/10.1016/j.nicl.2017.04.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Fan, Jie
Zhong, Mingtian
Zhu, Xiongzhao
Gan, Jun
Liu, Wanting
Niu, Chaoyang
Liao, Haiyan
Zhang, Hongchun
Yi, Jinyao
Tan, Changlian
Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder
title Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder
title_full Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder
title_fullStr Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder
title_full_unstemmed Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder
title_short Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder
title_sort resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397581/
https://www.ncbi.nlm.nih.gov/pubmed/28458998
http://dx.doi.org/10.1016/j.nicl.2017.04.002
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