Prediction and Reduction of the Aggregation of Monoclonal Antibodies

Protein aggregation remains a major area of focus in the production of monoclonal antibodies. Improving the intrinsic properties of antibodies can improve manufacturability, attrition rates, safety, formulation, titers, immunogenicity, and solubility. Here, we explore the potential of predicting and...

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Detalles Bibliográficos
Autores principales: van der Kant, Rob, Karow-Zwick, Anne R., Van Durme, Joost, Blech, Michaela, Gallardo, Rodrigo, Seeliger, Daniel, Aßfalg, Kerstin, Baatsen, Pieter, Compernolle, Griet, Gils, Ann, Studts, Joey M., Schulz, Patrick, Garidel, Patrick, Schymkowitz, Joost, Rousseau, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397608/
https://www.ncbi.nlm.nih.gov/pubmed/28322916
http://dx.doi.org/10.1016/j.jmb.2017.03.014

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