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Gastrointestinal Stromal Tumor Induced Hypercalcemia

Hypercalcemia in patients with cancer is a common laboratory finding affecting up to 44% of that patient population. 1,25-Dihydroxyvitamin D(3) mediated hypercalcemia is one of the rare mechanisms of this endocrine emergency in cancer patients. It is even rarer for solid organ neoplasms to present w...

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Autores principales: Barbaryan, Aram, Bailuc, Stefania, Poddutoori, Padma, Richardson, Aida, Mirrakhimov, Aibek E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397646/
https://www.ncbi.nlm.nih.gov/pubmed/28484656
http://dx.doi.org/10.1155/2017/4972017
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author Barbaryan, Aram
Bailuc, Stefania
Poddutoori, Padma
Richardson, Aida
Mirrakhimov, Aibek E.
author_facet Barbaryan, Aram
Bailuc, Stefania
Poddutoori, Padma
Richardson, Aida
Mirrakhimov, Aibek E.
author_sort Barbaryan, Aram
collection PubMed
description Hypercalcemia in patients with cancer is a common laboratory finding affecting up to 44% of that patient population. 1,25-Dihydroxyvitamin D(3) mediated hypercalcemia is one of the rare mechanisms of this endocrine emergency in cancer patients. It is even rarer for solid organ neoplasms to present with hypercalcemia mediated through the production of 1,25-dihydroxyvitamin D(3). We report a case of a 77-year-old female who presented to the hospital with hypercalcemia and later was found to have metastatic gastrointestinal stromal tumor. There have been only 5 cases of gastrointestinal stromal tumor described in literature resulting in hypercalcemia. In our case, the mechanism of hypercalcemia was thought to be related to overproduction of 1,25-dihydroxyvitamin by tumor cells. The patient had a favorable response to imatinib with normalization of serum calcium level. Unfortunately, she developed fluid retention due to imatinib which was discontinued resulting in relapse of hypercalcemia that was resistant to all other treatment options.
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spelling pubmed-53976462017-05-08 Gastrointestinal Stromal Tumor Induced Hypercalcemia Barbaryan, Aram Bailuc, Stefania Poddutoori, Padma Richardson, Aida Mirrakhimov, Aibek E. Case Rep Oncol Med Case Report Hypercalcemia in patients with cancer is a common laboratory finding affecting up to 44% of that patient population. 1,25-Dihydroxyvitamin D(3) mediated hypercalcemia is one of the rare mechanisms of this endocrine emergency in cancer patients. It is even rarer for solid organ neoplasms to present with hypercalcemia mediated through the production of 1,25-dihydroxyvitamin D(3). We report a case of a 77-year-old female who presented to the hospital with hypercalcemia and later was found to have metastatic gastrointestinal stromal tumor. There have been only 5 cases of gastrointestinal stromal tumor described in literature resulting in hypercalcemia. In our case, the mechanism of hypercalcemia was thought to be related to overproduction of 1,25-dihydroxyvitamin by tumor cells. The patient had a favorable response to imatinib with normalization of serum calcium level. Unfortunately, she developed fluid retention due to imatinib which was discontinued resulting in relapse of hypercalcemia that was resistant to all other treatment options. Hindawi 2017 2017-04-06 /pmc/articles/PMC5397646/ /pubmed/28484656 http://dx.doi.org/10.1155/2017/4972017 Text en Copyright © 2017 Aram Barbaryan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Barbaryan, Aram
Bailuc, Stefania
Poddutoori, Padma
Richardson, Aida
Mirrakhimov, Aibek E.
Gastrointestinal Stromal Tumor Induced Hypercalcemia
title Gastrointestinal Stromal Tumor Induced Hypercalcemia
title_full Gastrointestinal Stromal Tumor Induced Hypercalcemia
title_fullStr Gastrointestinal Stromal Tumor Induced Hypercalcemia
title_full_unstemmed Gastrointestinal Stromal Tumor Induced Hypercalcemia
title_short Gastrointestinal Stromal Tumor Induced Hypercalcemia
title_sort gastrointestinal stromal tumor induced hypercalcemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397646/
https://www.ncbi.nlm.nih.gov/pubmed/28484656
http://dx.doi.org/10.1155/2017/4972017
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