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Intrusions in episodic memory: reconsolidation or interference?

It would be profoundly important if reconsolidation research in animals and other memory domains generalized to human episodic memory. A 3-d-list-discrimination procedure, based on free recall of objects, with a contextual reminder cue (the testing room), has been thought to demonstrate reconsolidat...

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Autores principales: Klingmüller, Angela, Caplan, Jeremy B., Sommer, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397684/
https://www.ncbi.nlm.nih.gov/pubmed/28416633
http://dx.doi.org/10.1101/lm.045047.117
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author Klingmüller, Angela
Caplan, Jeremy B.
Sommer, Tobias
author_facet Klingmüller, Angela
Caplan, Jeremy B.
Sommer, Tobias
author_sort Klingmüller, Angela
collection PubMed
description It would be profoundly important if reconsolidation research in animals and other memory domains generalized to human episodic memory. A 3-d-list-discrimination procedure, based on free recall of objects, with a contextual reminder cue (the testing room), has been thought to demonstrate reconsolidation of human episodic memory (as noted in a previous study). Our goal was to replicate the central result, a high intrusion rate during recall of the target list, and evaluate the reconsolidation account relative to an alternative account, based on state-dependent learning and interference. First, replication was not straightforward (Experiment 1). Second, using a very unique, highly salient context (Experiment 2), the method produced a qualitative replication, but it was small in magnitude. A critical assumption of the reconsolidation account, that the target list is reactivated and destabilized during re-exposure to the study context, was not supported (Experiment 3). Although troubling for the reconsolidation account, the findings can be easily accommodated by an alternative account that does not assume additional neurobiological processes underlying the destabilization of consolidated memories, instead explaining intrusion rates simply in terms of well-established cognitive effects, such as item-to-context binding and interference during retrieval.
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spelling pubmed-53976842018-05-01 Intrusions in episodic memory: reconsolidation or interference? Klingmüller, Angela Caplan, Jeremy B. Sommer, Tobias Learn Mem Research It would be profoundly important if reconsolidation research in animals and other memory domains generalized to human episodic memory. A 3-d-list-discrimination procedure, based on free recall of objects, with a contextual reminder cue (the testing room), has been thought to demonstrate reconsolidation of human episodic memory (as noted in a previous study). Our goal was to replicate the central result, a high intrusion rate during recall of the target list, and evaluate the reconsolidation account relative to an alternative account, based on state-dependent learning and interference. First, replication was not straightforward (Experiment 1). Second, using a very unique, highly salient context (Experiment 2), the method produced a qualitative replication, but it was small in magnitude. A critical assumption of the reconsolidation account, that the target list is reactivated and destabilized during re-exposure to the study context, was not supported (Experiment 3). Although troubling for the reconsolidation account, the findings can be easily accommodated by an alternative account that does not assume additional neurobiological processes underlying the destabilization of consolidated memories, instead explaining intrusion rates simply in terms of well-established cognitive effects, such as item-to-context binding and interference during retrieval. Cold Spring Harbor Laboratory Press 2017-05 /pmc/articles/PMC5397684/ /pubmed/28416633 http://dx.doi.org/10.1101/lm.045047.117 Text en © 2017 Klingmüller et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research
Klingmüller, Angela
Caplan, Jeremy B.
Sommer, Tobias
Intrusions in episodic memory: reconsolidation or interference?
title Intrusions in episodic memory: reconsolidation or interference?
title_full Intrusions in episodic memory: reconsolidation or interference?
title_fullStr Intrusions in episodic memory: reconsolidation or interference?
title_full_unstemmed Intrusions in episodic memory: reconsolidation or interference?
title_short Intrusions in episodic memory: reconsolidation or interference?
title_sort intrusions in episodic memory: reconsolidation or interference?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397684/
https://www.ncbi.nlm.nih.gov/pubmed/28416633
http://dx.doi.org/10.1101/lm.045047.117
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