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Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA

BACKGROUND: The discovery that 5-methylcytosine (5mC) can be oxidized to 5-hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted wide interest in the potential role of 5hmC in reshaping the mammalian DNA methylation landscape. The gold-standard bisulphite conversio...

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Detalles Bibliográficos
Autores principales:	Skvortsova, Ksenia, Zotenko, Elena, Luu, Phuc-Loi, Gould, Cathryn M., Nair, Shalima S., Clark, Susan J., Stirzaker, Clare
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397694/ https://www.ncbi.nlm.nih.gov/pubmed/28428825 http://dx.doi.org/10.1186/s13072-017-0123-7

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