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Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort

BACKGROUND: Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period. METHODS: The community-based c...

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Autores principales: Carrière, Isabelle, Norton, Joanna, Farré, Amandine, Wyart, Marilyn, Tzourio, Christophe, Noize, Pernelle, Pérès, Karine, Fourrier-Réglat, Annie, Ritchie, Karen, Ancelin, Marie Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397783/
https://www.ncbi.nlm.nih.gov/pubmed/28424070
http://dx.doi.org/10.1186/s12916-017-0847-z
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author Carrière, Isabelle
Norton, Joanna
Farré, Amandine
Wyart, Marilyn
Tzourio, Christophe
Noize, Pernelle
Pérès, Karine
Fourrier-Réglat, Annie
Ritchie, Karen
Ancelin, Marie Laure
author_facet Carrière, Isabelle
Norton, Joanna
Farré, Amandine
Wyart, Marilyn
Tzourio, Christophe
Noize, Pernelle
Pérès, Karine
Fourrier-Réglat, Annie
Ritchie, Karen
Ancelin, Marie Laure
author_sort Carrière, Isabelle
collection PubMed
description BACKGROUND: Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period. METHODS: The community-based cohort included 7381 participants aged 65 years and above. Five cognitive domains (verbal fluency, psychomotor speed, executive function, visuospatial skills and global cognition) were assessed up to five times over 10 years of follow-up. Treatment groups included participants under a specific antidepressant class at both baseline and the first follow-up and their follow-up cognitive data were considered until the last consecutive follow-up with a report of antidepressant use of the same class. Linear mixed models were used to compare baseline cognitive performance and cognitive decline over time according to antidepressant treatment. The models were adjusted for multiple confounders including residual depressive symptoms assessed by the Center for Epidemiologic Studies-Depression scale. RESULTS: At baseline, 4.0% of participants were taking antidepressants. Compared to non-users, tricyclic antidepressant users had lower baseline performances in verbal fluency, visual memory and psychomotor speed, and selective serotonin reuptake inhibitor users in verbal fluency and psychomotor speed. For the two other cognitive abilities, executive function and global cognition, no significant differences were found at baseline irrespective of the antidepressant class. Regarding changes over time, no significant differences were observed in comparison with non-users whatever the cognitive domain, except for a slight additional improvement over the follow-up in verbal fluency skills for tricyclic antidepressant users. CONCLUSIONS: In this large elderly general population cohort, we found no evidence for an association between antidepressant use and post-treatment cognitive decline over 10 years of follow-up in various cognitive domains. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12916-017-0847-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-53977832017-04-21 Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort Carrière, Isabelle Norton, Joanna Farré, Amandine Wyart, Marilyn Tzourio, Christophe Noize, Pernelle Pérès, Karine Fourrier-Réglat, Annie Ritchie, Karen Ancelin, Marie Laure BMC Med Research Article BACKGROUND: Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period. METHODS: The community-based cohort included 7381 participants aged 65 years and above. Five cognitive domains (verbal fluency, psychomotor speed, executive function, visuospatial skills and global cognition) were assessed up to five times over 10 years of follow-up. Treatment groups included participants under a specific antidepressant class at both baseline and the first follow-up and their follow-up cognitive data were considered until the last consecutive follow-up with a report of antidepressant use of the same class. Linear mixed models were used to compare baseline cognitive performance and cognitive decline over time according to antidepressant treatment. The models were adjusted for multiple confounders including residual depressive symptoms assessed by the Center for Epidemiologic Studies-Depression scale. RESULTS: At baseline, 4.0% of participants were taking antidepressants. Compared to non-users, tricyclic antidepressant users had lower baseline performances in verbal fluency, visual memory and psychomotor speed, and selective serotonin reuptake inhibitor users in verbal fluency and psychomotor speed. For the two other cognitive abilities, executive function and global cognition, no significant differences were found at baseline irrespective of the antidepressant class. Regarding changes over time, no significant differences were observed in comparison with non-users whatever the cognitive domain, except for a slight additional improvement over the follow-up in verbal fluency skills for tricyclic antidepressant users. CONCLUSIONS: In this large elderly general population cohort, we found no evidence for an association between antidepressant use and post-treatment cognitive decline over 10 years of follow-up in various cognitive domains. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12916-017-0847-z) contains supplementary material, which is available to authorized users. BioMed Central 2017-04-19 /pmc/articles/PMC5397783/ /pubmed/28424070 http://dx.doi.org/10.1186/s12916-017-0847-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Carrière, Isabelle
Norton, Joanna
Farré, Amandine
Wyart, Marilyn
Tzourio, Christophe
Noize, Pernelle
Pérès, Karine
Fourrier-Réglat, Annie
Ritchie, Karen
Ancelin, Marie Laure
Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort
title Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort
title_full Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort
title_fullStr Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort
title_full_unstemmed Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort
title_short Antidepressant use and cognitive decline in community-dwelling elderly people – The Three-City Cohort
title_sort antidepressant use and cognitive decline in community-dwelling elderly people – the three-city cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397783/
https://www.ncbi.nlm.nih.gov/pubmed/28424070
http://dx.doi.org/10.1186/s12916-017-0847-z
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