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Nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise
Many forms of synaptic plasticity require the local production of volatile or rapidly diffusing substances such as nitric oxide. The nonspecific plasticity these neuromodulators may induce at neighboring non-active synapses is thought to be detrimental for the specificity of memory storage. We show...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397845/ https://www.ncbi.nlm.nih.gov/pubmed/28425471 http://dx.doi.org/10.1038/srep46550 |
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author | Safaryan, Karen Maex, Reinoud Davey, Neil Adams, Rod Steuber, Volker |
author_facet | Safaryan, Karen Maex, Reinoud Davey, Neil Adams, Rod Steuber, Volker |
author_sort | Safaryan, Karen |
collection | PubMed |
description | Many forms of synaptic plasticity require the local production of volatile or rapidly diffusing substances such as nitric oxide. The nonspecific plasticity these neuromodulators may induce at neighboring non-active synapses is thought to be detrimental for the specificity of memory storage. We show here that memory retrieval may benefit from this non-specific plasticity when the applied sparse binary input patterns are degraded by local noise. Simulations of a biophysically realistic model of a cerebellar Purkinje cell in a pattern recognition task show that, in the absence of noise, leakage of plasticity to adjacent synapses degrades the recognition of sparse static patterns. However, above a local noise level of 20%, the model with nonspecific plasticity outperforms the standard, specific model. The gain in performance is greatest when the spatial distribution of noise in the input matches the range of diffusion-induced plasticity. Hence non-specific plasticity may offer a benefit in noisy environments or when the pressure to generalize is strong. |
format | Online Article Text |
id | pubmed-5397845 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53978452017-04-21 Nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise Safaryan, Karen Maex, Reinoud Davey, Neil Adams, Rod Steuber, Volker Sci Rep Article Many forms of synaptic plasticity require the local production of volatile or rapidly diffusing substances such as nitric oxide. The nonspecific plasticity these neuromodulators may induce at neighboring non-active synapses is thought to be detrimental for the specificity of memory storage. We show here that memory retrieval may benefit from this non-specific plasticity when the applied sparse binary input patterns are degraded by local noise. Simulations of a biophysically realistic model of a cerebellar Purkinje cell in a pattern recognition task show that, in the absence of noise, leakage of plasticity to adjacent synapses degrades the recognition of sparse static patterns. However, above a local noise level of 20%, the model with nonspecific plasticity outperforms the standard, specific model. The gain in performance is greatest when the spatial distribution of noise in the input matches the range of diffusion-induced plasticity. Hence non-specific plasticity may offer a benefit in noisy environments or when the pressure to generalize is strong. Nature Publishing Group 2017-04-20 /pmc/articles/PMC5397845/ /pubmed/28425471 http://dx.doi.org/10.1038/srep46550 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Safaryan, Karen Maex, Reinoud Davey, Neil Adams, Rod Steuber, Volker Nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise |
title | Nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise |
title_full | Nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise |
title_fullStr | Nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise |
title_full_unstemmed | Nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise |
title_short | Nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise |
title_sort | nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397845/ https://www.ncbi.nlm.nih.gov/pubmed/28425471 http://dx.doi.org/10.1038/srep46550 |
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