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The epidemiology of cryptococcosis and the characterization of Cryptococcus neoformans isolated in a Brazilian University Hospital
Cryptococcosis, a systemic disease caused by the fungus Cryptococcus neoformans/ Cryptococcus gattii is more severe in immunocompromised individuals. This study aimed to analyze the epidemiology of the disease, the molecular characteristics and the antifungal susceptibility of C. neoformans isolated...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto de Medicina Tropical
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398185/ https://www.ncbi.nlm.nih.gov/pubmed/28423088 http://dx.doi.org/10.1590/S1678-9946201759013 |
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author | de Aguiar, Paula Augusta Dias Fogaça Pedroso, Reginaldo dos Santos Borges, Aércio Sebastião Moreira, Tomaz de Aquino de Araújo, Lúcio Borges Röder, Denise Von Dolinger de Brito |
author_facet | de Aguiar, Paula Augusta Dias Fogaça Pedroso, Reginaldo dos Santos Borges, Aércio Sebastião Moreira, Tomaz de Aquino de Araújo, Lúcio Borges Röder, Denise Von Dolinger de Brito |
author_sort | de Aguiar, Paula Augusta Dias Fogaça |
collection | PubMed |
description | Cryptococcosis, a systemic disease caused by the fungus Cryptococcus neoformans/ Cryptococcus gattii is more severe in immunocompromised individuals. This study aimed to analyze the epidemiology of the disease, the molecular characteristics and the antifungal susceptibility of C. neoformans isolated from patients treated in a Brazilian university hospital. This retrospective study was conducted in the Clinical Hospital, Federal University of Uberlândia, and evaluated cases of cryptococcosis and strains of C. neoformans isolated from 2004 to 2013. We evaluated 41 patients, 85% of whom were diagnosed with AIDS. The fungus was isolated from the cerebrospinal fluid (CSF) of 21 patients (51%); 19.5% had fungemia and in 24% the agent was isolated from the CSF and blood, concurrently. Meningoencephalitis was the most frequent (75%) manifestation of infection. Despite adequate treatment, the mortality of the disease was 58.5%. Most isolates (97.5%) presented the VNI genotype (serotype A, var. grubii) and one isolate was genotyped as C. gattii (VGI); all the isolates were determined as mating type MATa and showed susceptibility to the tested antifungals (fluconazole, voriconazole, amphotericin B and 5-flucytosine). Although AIDS detection rates remain stable, opportunistic infections such as cryptococcosis remain as major causes of morbidity and mortality in these patients. |
format | Online Article Text |
id | pubmed-5398185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Instituto de Medicina Tropical |
record_format | MEDLINE/PubMed |
spelling | pubmed-53981852017-04-27 The epidemiology of cryptococcosis and the characterization of Cryptococcus neoformans isolated in a Brazilian University Hospital de Aguiar, Paula Augusta Dias Fogaça Pedroso, Reginaldo dos Santos Borges, Aércio Sebastião Moreira, Tomaz de Aquino de Araújo, Lúcio Borges Röder, Denise Von Dolinger de Brito Rev Inst Med Trop Sao Paulo Original Article Cryptococcosis, a systemic disease caused by the fungus Cryptococcus neoformans/ Cryptococcus gattii is more severe in immunocompromised individuals. This study aimed to analyze the epidemiology of the disease, the molecular characteristics and the antifungal susceptibility of C. neoformans isolated from patients treated in a Brazilian university hospital. This retrospective study was conducted in the Clinical Hospital, Federal University of Uberlândia, and evaluated cases of cryptococcosis and strains of C. neoformans isolated from 2004 to 2013. We evaluated 41 patients, 85% of whom were diagnosed with AIDS. The fungus was isolated from the cerebrospinal fluid (CSF) of 21 patients (51%); 19.5% had fungemia and in 24% the agent was isolated from the CSF and blood, concurrently. Meningoencephalitis was the most frequent (75%) manifestation of infection. Despite adequate treatment, the mortality of the disease was 58.5%. Most isolates (97.5%) presented the VNI genotype (serotype A, var. grubii) and one isolate was genotyped as C. gattii (VGI); all the isolates were determined as mating type MATa and showed susceptibility to the tested antifungals (fluconazole, voriconazole, amphotericin B and 5-flucytosine). Although AIDS detection rates remain stable, opportunistic infections such as cryptococcosis remain as major causes of morbidity and mortality in these patients. Instituto de Medicina Tropical 2017-04-13 /pmc/articles/PMC5398185/ /pubmed/28423088 http://dx.doi.org/10.1590/S1678-9946201759013 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Original Article de Aguiar, Paula Augusta Dias Fogaça Pedroso, Reginaldo dos Santos Borges, Aércio Sebastião Moreira, Tomaz de Aquino de Araújo, Lúcio Borges Röder, Denise Von Dolinger de Brito The epidemiology of cryptococcosis and the characterization of Cryptococcus neoformans isolated in a Brazilian University Hospital |
title | The epidemiology of cryptococcosis and the characterization of Cryptococcus neoformans isolated in a Brazilian University Hospital |
title_full | The epidemiology of cryptococcosis and the characterization of Cryptococcus neoformans isolated in a Brazilian University Hospital |
title_fullStr | The epidemiology of cryptococcosis and the characterization of Cryptococcus neoformans isolated in a Brazilian University Hospital |
title_full_unstemmed | The epidemiology of cryptococcosis and the characterization of Cryptococcus neoformans isolated in a Brazilian University Hospital |
title_short | The epidemiology of cryptococcosis and the characterization of Cryptococcus neoformans isolated in a Brazilian University Hospital |
title_sort | epidemiology of cryptococcosis and the characterization of cryptococcus neoformans isolated in a brazilian university hospital |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398185/ https://www.ncbi.nlm.nih.gov/pubmed/28423088 http://dx.doi.org/10.1590/S1678-9946201759013 |
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