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Un purpura thrombopénique amégacaryocytaire acquis qui cache une leucémie aigue myéloblastique

Acquired amegakaryocytic thrombocytopenic purpura is a very rare condition characterized by severe thrombocytopenia linked to the reduction or disappearance of megakaryocytes in the bone marrow. It may be primary idiopathic or secondary to many pathological conditions including hematologic disorders...

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Autores principales: Eddou, Hicham, Zinebi, Ali, Khalloufi, Abdelaziz, Sina, Mohammed, Mahtat, Mehdi, Doghmi, Kamal, Mikdame, Mohammed, Moudden, Mohammed Karim, Baaj, Mohammed El
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398219/
https://www.ncbi.nlm.nih.gov/pubmed/28451010
http://dx.doi.org/10.11604/pamj.2017.26.32.9215
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author Eddou, Hicham
Zinebi, Ali
Khalloufi, Abdelaziz
Sina, Mohammed
Mahtat, Mehdi
Doghmi, Kamal
Mikdame, Mohammed
Moudden, Mohammed Karim
Baaj, Mohammed El
author_facet Eddou, Hicham
Zinebi, Ali
Khalloufi, Abdelaziz
Sina, Mohammed
Mahtat, Mehdi
Doghmi, Kamal
Mikdame, Mohammed
Moudden, Mohammed Karim
Baaj, Mohammed El
author_sort Eddou, Hicham
collection PubMed
description Acquired amegakaryocytic thrombocytopenic purpura is a very rare condition characterized by severe thrombocytopenia linked to the reduction or disappearance of megakaryocytes in the bone marrow. It may be primary idiopathic or secondary to many pathological conditions including hematologic disorders. We report the case of a 24-year-old patient admitted for haemorrhagic syndrome caused by immunological thrombocytopenic purpura. The diagnosis was acquired amegakaryocytosis after the failure of corticotherapy and the performance of myelography. The patient was treated with ciclosporin with rapid progression to acute myeloblastic leukemia. The progression of acquired amegakaryocytosis to acute leukemia is reported but it is generally not so rapid and above all it is preceded by myelodysplastic syndrome or medullary aplasia. This study highlights the importance of a close follow-up of these pathologies with a benign-like appearance.
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spelling pubmed-53982192017-04-27 Un purpura thrombopénique amégacaryocytaire acquis qui cache une leucémie aigue myéloblastique Eddou, Hicham Zinebi, Ali Khalloufi, Abdelaziz Sina, Mohammed Mahtat, Mehdi Doghmi, Kamal Mikdame, Mohammed Moudden, Mohammed Karim Baaj, Mohammed El Pan Afr Med J Case Report Acquired amegakaryocytic thrombocytopenic purpura is a very rare condition characterized by severe thrombocytopenia linked to the reduction or disappearance of megakaryocytes in the bone marrow. It may be primary idiopathic or secondary to many pathological conditions including hematologic disorders. We report the case of a 24-year-old patient admitted for haemorrhagic syndrome caused by immunological thrombocytopenic purpura. The diagnosis was acquired amegakaryocytosis after the failure of corticotherapy and the performance of myelography. The patient was treated with ciclosporin with rapid progression to acute myeloblastic leukemia. The progression of acquired amegakaryocytosis to acute leukemia is reported but it is generally not so rapid and above all it is preceded by myelodysplastic syndrome or medullary aplasia. This study highlights the importance of a close follow-up of these pathologies with a benign-like appearance. The African Field Epidemiology Network 2017-01-23 /pmc/articles/PMC5398219/ /pubmed/28451010 http://dx.doi.org/10.11604/pamj.2017.26.32.9215 Text en © Hicham Eddou et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Eddou, Hicham
Zinebi, Ali
Khalloufi, Abdelaziz
Sina, Mohammed
Mahtat, Mehdi
Doghmi, Kamal
Mikdame, Mohammed
Moudden, Mohammed Karim
Baaj, Mohammed El
Un purpura thrombopénique amégacaryocytaire acquis qui cache une leucémie aigue myéloblastique
title Un purpura thrombopénique amégacaryocytaire acquis qui cache une leucémie aigue myéloblastique
title_full Un purpura thrombopénique amégacaryocytaire acquis qui cache une leucémie aigue myéloblastique
title_fullStr Un purpura thrombopénique amégacaryocytaire acquis qui cache une leucémie aigue myéloblastique
title_full_unstemmed Un purpura thrombopénique amégacaryocytaire acquis qui cache une leucémie aigue myéloblastique
title_short Un purpura thrombopénique amégacaryocytaire acquis qui cache une leucémie aigue myéloblastique
title_sort un purpura thrombopénique amégacaryocytaire acquis qui cache une leucémie aigue myéloblastique
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398219/
https://www.ncbi.nlm.nih.gov/pubmed/28451010
http://dx.doi.org/10.11604/pamj.2017.26.32.9215
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