Cargando…

Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer

PURPOSE: The purpose of this study was to analyze clinical outcomes from cervical cancer and stratify patients into risk groups for prognostic factors for early-stage disease. MATERIALS AND METHODS: We retrospectively reviewed patients with stage IB or IIA cervical cancer treated with adjuvant radio...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Kyungmi, Park, Won, Huh, Seung Jae, Bae, Duk-Soo, Kim, Byoung-Gie, Lee, Jeong-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Radiation Oncology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398353/
https://www.ncbi.nlm.nih.gov/pubmed/27927011
http://dx.doi.org/10.3857/roj.2016.01893
_version_ 1783230450251071488
author Yang, Kyungmi
Park, Won
Huh, Seung Jae
Bae, Duk-Soo
Kim, Byoung-Gie
Lee, Jeong-Won
author_facet Yang, Kyungmi
Park, Won
Huh, Seung Jae
Bae, Duk-Soo
Kim, Byoung-Gie
Lee, Jeong-Won
author_sort Yang, Kyungmi
collection PubMed
description PURPOSE: The purpose of this study was to analyze clinical outcomes from cervical cancer and stratify patients into risk groups for prognostic factors for early-stage disease. MATERIALS AND METHODS: We retrospectively reviewed patients with stage IB or IIA cervical cancer treated with adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) following primary surgery at Samsung Medical Center from 2001 to 2011. Adjuvant RT was added for patients with intermediate-risk factors, and adjuvant CCRT was performed on high-risk patients after surgery. RESULTS: We reviewed 247 patients—149 in the high-risk group and 98 in intermediate-risk group. The median follow-up was 62 months. Loco-regional failure (LRF) alone occurred in 7 patients (2.8%), distant metastasis alone in 37 patients (15.0%) and LRF with DM in 4 patients (1.6%). The 5-year disease-free survival (DFS) and overall survival (OS) rates for both groups were 79.7% and 87.6%, respectively. In the high-risk group, the 5-year DFS and OS probabilities were 72.5% and 81.9%, respectively. Histologic type, pathologic tumor size, and the number of pelvic lymph node (PLN) metastasis were significant prognostic factors for DFS and OS. We suggest a scoring system (0–3) using these prognostic factors to predict poor prognosis in high-risk patients. Using this system, patients with higher scores have higher recurrence and lower survival rates. CONCLUSION: In the high-risk cervical-cancer group who received primary surgery and adjuvant CCRT, non-squamous type, large tumor size and the number of PLN metastasis were significant prognostic factors, and the number of these factors was associated with survival rates.
format Online
Article
Text
id pubmed-5398353
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Korean Society for Radiation Oncology
record_format MEDLINE/PubMed
spelling pubmed-53983532017-05-05 Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer Yang, Kyungmi Park, Won Huh, Seung Jae Bae, Duk-Soo Kim, Byoung-Gie Lee, Jeong-Won Radiat Oncol J Original Article PURPOSE: The purpose of this study was to analyze clinical outcomes from cervical cancer and stratify patients into risk groups for prognostic factors for early-stage disease. MATERIALS AND METHODS: We retrospectively reviewed patients with stage IB or IIA cervical cancer treated with adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) following primary surgery at Samsung Medical Center from 2001 to 2011. Adjuvant RT was added for patients with intermediate-risk factors, and adjuvant CCRT was performed on high-risk patients after surgery. RESULTS: We reviewed 247 patients—149 in the high-risk group and 98 in intermediate-risk group. The median follow-up was 62 months. Loco-regional failure (LRF) alone occurred in 7 patients (2.8%), distant metastasis alone in 37 patients (15.0%) and LRF with DM in 4 patients (1.6%). The 5-year disease-free survival (DFS) and overall survival (OS) rates for both groups were 79.7% and 87.6%, respectively. In the high-risk group, the 5-year DFS and OS probabilities were 72.5% and 81.9%, respectively. Histologic type, pathologic tumor size, and the number of pelvic lymph node (PLN) metastasis were significant prognostic factors for DFS and OS. We suggest a scoring system (0–3) using these prognostic factors to predict poor prognosis in high-risk patients. Using this system, patients with higher scores have higher recurrence and lower survival rates. CONCLUSION: In the high-risk cervical-cancer group who received primary surgery and adjuvant CCRT, non-squamous type, large tumor size and the number of PLN metastasis were significant prognostic factors, and the number of these factors was associated with survival rates. The Korean Society for Radiation Oncology 2017-03 2016-12-12 /pmc/articles/PMC5398353/ /pubmed/27927011 http://dx.doi.org/10.3857/roj.2016.01893 Text en Copyright © 2017 The Korean Society for Radiation Oncology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yang, Kyungmi
Park, Won
Huh, Seung Jae
Bae, Duk-Soo
Kim, Byoung-Gie
Lee, Jeong-Won
Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer
title Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer
title_full Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer
title_fullStr Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer
title_full_unstemmed Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer
title_short Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer
title_sort clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398353/
https://www.ncbi.nlm.nih.gov/pubmed/27927011
http://dx.doi.org/10.3857/roj.2016.01893
work_keys_str_mv AT yangkyungmi clinicaloutcomesinpatientstreatedwithradiotherapyaftersurgeryforcervicalcancer
AT parkwon clinicaloutcomesinpatientstreatedwithradiotherapyaftersurgeryforcervicalcancer
AT huhseungjae clinicaloutcomesinpatientstreatedwithradiotherapyaftersurgeryforcervicalcancer
AT baeduksoo clinicaloutcomesinpatientstreatedwithradiotherapyaftersurgeryforcervicalcancer
AT kimbyounggie clinicaloutcomesinpatientstreatedwithradiotherapyaftersurgeryforcervicalcancer
AT leejeongwon clinicaloutcomesinpatientstreatedwithradiotherapyaftersurgeryforcervicalcancer