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Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study

OBJECTIVE: To report the echocardiographic evaluation of 103 infants with presumed congenital Zika syndrome. METHODS: An observational retrospective study was performed at Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil. 103 infants with presumed congenital Zika syndrom...

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Autores principales: Cavalcanti, Danielle Di, Alves, Lucas V., Furtado, Geraldo J., Santos, Cleusa C., Feitosa, Fabiana G., Ribeiro, Maria C., Menge, Paulo, Lira, Izabelle M., Alves, Joao G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398518/
https://www.ncbi.nlm.nih.gov/pubmed/28426680
http://dx.doi.org/10.1371/journal.pone.0175065
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author Cavalcanti, Danielle Di
Alves, Lucas V.
Furtado, Geraldo J.
Santos, Cleusa C.
Feitosa, Fabiana G.
Ribeiro, Maria C.
Menge, Paulo
Lira, Izabelle M.
Alves, Joao G.
author_facet Cavalcanti, Danielle Di
Alves, Lucas V.
Furtado, Geraldo J.
Santos, Cleusa C.
Feitosa, Fabiana G.
Ribeiro, Maria C.
Menge, Paulo
Lira, Izabelle M.
Alves, Joao G.
author_sort Cavalcanti, Danielle Di
collection PubMed
description OBJECTIVE: To report the echocardiographic evaluation of 103 infants with presumed congenital Zika syndrome. METHODS: An observational retrospective study was performed at Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil. 103 infants with presumed congenital Zika syndrome. All infants had microcephaly and head computed tomography findings compatible with congenital Zika syndrome. Zika IgM antibody was detected in cerebrospinal fluid samples of 23 infants. In 80 infants, the test was not performed because it was not available at that time. All infants had negative serology for HIV, syphilis, rubella, cytomegalovirus and toxoplasmosis. A complete transthoracic two-dimensional, M-mode, continuous wave and pulsed wave Doppler and color Doppler echocardiographic (PHILIPS HD11XE or HD15) examination was performed on all infants. RESULTS: 14/103 (13.5%) echocardiograms were compatible with congenital heart disease: 5 with an ostium secundum atrial septal defect, 8 had a hemodynamically insignificant small apical muscular ventricular septal defect and one infant with dyspnea had a large membranous ventricular septal defect. The echocardiograms considered normal included 45 infants with a persistent foramen ovale and 16 with a minimum patent ductus arteriosus. CONCLUSIONS: Preliminarily this study suggests that congenital Zika syndrome may be associated with an increase prevalence of congenital heart disease. However the types of defects noted were septal defects, a proportion of which would not be hemodynamically significant.
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spelling pubmed-53985182017-05-04 Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study Cavalcanti, Danielle Di Alves, Lucas V. Furtado, Geraldo J. Santos, Cleusa C. Feitosa, Fabiana G. Ribeiro, Maria C. Menge, Paulo Lira, Izabelle M. Alves, Joao G. PLoS One Research Article OBJECTIVE: To report the echocardiographic evaluation of 103 infants with presumed congenital Zika syndrome. METHODS: An observational retrospective study was performed at Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Brazil. 103 infants with presumed congenital Zika syndrome. All infants had microcephaly and head computed tomography findings compatible with congenital Zika syndrome. Zika IgM antibody was detected in cerebrospinal fluid samples of 23 infants. In 80 infants, the test was not performed because it was not available at that time. All infants had negative serology for HIV, syphilis, rubella, cytomegalovirus and toxoplasmosis. A complete transthoracic two-dimensional, M-mode, continuous wave and pulsed wave Doppler and color Doppler echocardiographic (PHILIPS HD11XE or HD15) examination was performed on all infants. RESULTS: 14/103 (13.5%) echocardiograms were compatible with congenital heart disease: 5 with an ostium secundum atrial septal defect, 8 had a hemodynamically insignificant small apical muscular ventricular septal defect and one infant with dyspnea had a large membranous ventricular septal defect. The echocardiograms considered normal included 45 infants with a persistent foramen ovale and 16 with a minimum patent ductus arteriosus. CONCLUSIONS: Preliminarily this study suggests that congenital Zika syndrome may be associated with an increase prevalence of congenital heart disease. However the types of defects noted were septal defects, a proportion of which would not be hemodynamically significant. Public Library of Science 2017-04-20 /pmc/articles/PMC5398518/ /pubmed/28426680 http://dx.doi.org/10.1371/journal.pone.0175065 Text en © 2017 Cavalcanti et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cavalcanti, Danielle Di
Alves, Lucas V.
Furtado, Geraldo J.
Santos, Cleusa C.
Feitosa, Fabiana G.
Ribeiro, Maria C.
Menge, Paulo
Lira, Izabelle M.
Alves, Joao G.
Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study
title Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study
title_full Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study
title_fullStr Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study
title_full_unstemmed Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study
title_short Echocardiographic findings in infants with presumed congenital Zika syndrome: Retrospective case series study
title_sort echocardiographic findings in infants with presumed congenital zika syndrome: retrospective case series study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398518/
https://www.ncbi.nlm.nih.gov/pubmed/28426680
http://dx.doi.org/10.1371/journal.pone.0175065
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