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Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults

Brain atrophy is part of the aging process and accelerated by neurodegenerative diseases, so an understanding of the background heritability of brain volume is essential. The purpose of this study was to determine the heritability of brain volume in middle to advanced age East Asian adults, an age g...

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Autores principales: Lukies, Matthew W., Watanabe, Yoshiyuki, Tanaka, Hisashi, Takahashi, Hiroto, Ogata, Soshiro, Omura, Kayoko, Yorifuji, Shiro, Tomiyama, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398540/
https://www.ncbi.nlm.nih.gov/pubmed/28426696
http://dx.doi.org/10.1371/journal.pone.0175800
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author Lukies, Matthew W.
Watanabe, Yoshiyuki
Tanaka, Hisashi
Takahashi, Hiroto
Ogata, Soshiro
Omura, Kayoko
Yorifuji, Shiro
Tomiyama, Noriyuki
author_facet Lukies, Matthew W.
Watanabe, Yoshiyuki
Tanaka, Hisashi
Takahashi, Hiroto
Ogata, Soshiro
Omura, Kayoko
Yorifuji, Shiro
Tomiyama, Noriyuki
author_sort Lukies, Matthew W.
collection PubMed
description Brain atrophy is part of the aging process and accelerated by neurodegenerative diseases, so an understanding of the background heritability of brain volume is essential. The purpose of this study was to determine the heritability of brain volume in middle to advanced age East Asian adults, an age group less studied and an ethnicity not previously studied. 3T magnetic resonance images were obtained and volumetric analyses conducted for a total of 74 individuals, 20 monozygotic twin pairs (mean age 61y min 41y max 75y) and 17 dizygotic twin pairs (mean age 64y min 41y max 85y). Total brain volume and a further seven regions were assessed, including lobar volumes, lateral divisions, and separated grey and white matter. Additive genetics and unique environment (AE) models for global brain volumes including total brain (90%), grey matter (91%) and white matter (84%) and many lobar volumes demonstrated high heritability in our study population. Our results present the heritability of brain volume in middle to advanced age as possibly higher in East Asian adults.
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spelling pubmed-53985402017-05-04 Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults Lukies, Matthew W. Watanabe, Yoshiyuki Tanaka, Hisashi Takahashi, Hiroto Ogata, Soshiro Omura, Kayoko Yorifuji, Shiro Tomiyama, Noriyuki PLoS One Research Article Brain atrophy is part of the aging process and accelerated by neurodegenerative diseases, so an understanding of the background heritability of brain volume is essential. The purpose of this study was to determine the heritability of brain volume in middle to advanced age East Asian adults, an age group less studied and an ethnicity not previously studied. 3T magnetic resonance images were obtained and volumetric analyses conducted for a total of 74 individuals, 20 monozygotic twin pairs (mean age 61y min 41y max 75y) and 17 dizygotic twin pairs (mean age 64y min 41y max 85y). Total brain volume and a further seven regions were assessed, including lobar volumes, lateral divisions, and separated grey and white matter. Additive genetics and unique environment (AE) models for global brain volumes including total brain (90%), grey matter (91%) and white matter (84%) and many lobar volumes demonstrated high heritability in our study population. Our results present the heritability of brain volume in middle to advanced age as possibly higher in East Asian adults. Public Library of Science 2017-04-20 /pmc/articles/PMC5398540/ /pubmed/28426696 http://dx.doi.org/10.1371/journal.pone.0175800 Text en © 2017 Lukies et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lukies, Matthew W.
Watanabe, Yoshiyuki
Tanaka, Hisashi
Takahashi, Hiroto
Ogata, Soshiro
Omura, Kayoko
Yorifuji, Shiro
Tomiyama, Noriyuki
Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults
title Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults
title_full Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults
title_fullStr Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults
title_full_unstemmed Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults
title_short Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults
title_sort heritability of brain volume on mri in middle to advanced age: a twin study of japanese adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398540/
https://www.ncbi.nlm.nih.gov/pubmed/28426696
http://dx.doi.org/10.1371/journal.pone.0175800
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