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Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults
Brain atrophy is part of the aging process and accelerated by neurodegenerative diseases, so an understanding of the background heritability of brain volume is essential. The purpose of this study was to determine the heritability of brain volume in middle to advanced age East Asian adults, an age g...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398540/ https://www.ncbi.nlm.nih.gov/pubmed/28426696 http://dx.doi.org/10.1371/journal.pone.0175800 |
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author | Lukies, Matthew W. Watanabe, Yoshiyuki Tanaka, Hisashi Takahashi, Hiroto Ogata, Soshiro Omura, Kayoko Yorifuji, Shiro Tomiyama, Noriyuki |
author_facet | Lukies, Matthew W. Watanabe, Yoshiyuki Tanaka, Hisashi Takahashi, Hiroto Ogata, Soshiro Omura, Kayoko Yorifuji, Shiro Tomiyama, Noriyuki |
author_sort | Lukies, Matthew W. |
collection | PubMed |
description | Brain atrophy is part of the aging process and accelerated by neurodegenerative diseases, so an understanding of the background heritability of brain volume is essential. The purpose of this study was to determine the heritability of brain volume in middle to advanced age East Asian adults, an age group less studied and an ethnicity not previously studied. 3T magnetic resonance images were obtained and volumetric analyses conducted for a total of 74 individuals, 20 monozygotic twin pairs (mean age 61y min 41y max 75y) and 17 dizygotic twin pairs (mean age 64y min 41y max 85y). Total brain volume and a further seven regions were assessed, including lobar volumes, lateral divisions, and separated grey and white matter. Additive genetics and unique environment (AE) models for global brain volumes including total brain (90%), grey matter (91%) and white matter (84%) and many lobar volumes demonstrated high heritability in our study population. Our results present the heritability of brain volume in middle to advanced age as possibly higher in East Asian adults. |
format | Online Article Text |
id | pubmed-5398540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53985402017-05-04 Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults Lukies, Matthew W. Watanabe, Yoshiyuki Tanaka, Hisashi Takahashi, Hiroto Ogata, Soshiro Omura, Kayoko Yorifuji, Shiro Tomiyama, Noriyuki PLoS One Research Article Brain atrophy is part of the aging process and accelerated by neurodegenerative diseases, so an understanding of the background heritability of brain volume is essential. The purpose of this study was to determine the heritability of brain volume in middle to advanced age East Asian adults, an age group less studied and an ethnicity not previously studied. 3T magnetic resonance images were obtained and volumetric analyses conducted for a total of 74 individuals, 20 monozygotic twin pairs (mean age 61y min 41y max 75y) and 17 dizygotic twin pairs (mean age 64y min 41y max 85y). Total brain volume and a further seven regions were assessed, including lobar volumes, lateral divisions, and separated grey and white matter. Additive genetics and unique environment (AE) models for global brain volumes including total brain (90%), grey matter (91%) and white matter (84%) and many lobar volumes demonstrated high heritability in our study population. Our results present the heritability of brain volume in middle to advanced age as possibly higher in East Asian adults. Public Library of Science 2017-04-20 /pmc/articles/PMC5398540/ /pubmed/28426696 http://dx.doi.org/10.1371/journal.pone.0175800 Text en © 2017 Lukies et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lukies, Matthew W. Watanabe, Yoshiyuki Tanaka, Hisashi Takahashi, Hiroto Ogata, Soshiro Omura, Kayoko Yorifuji, Shiro Tomiyama, Noriyuki Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults |
title | Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults |
title_full | Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults |
title_fullStr | Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults |
title_full_unstemmed | Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults |
title_short | Heritability of brain volume on MRI in middle to advanced age: A twin study of Japanese adults |
title_sort | heritability of brain volume on mri in middle to advanced age: a twin study of japanese adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398540/ https://www.ncbi.nlm.nih.gov/pubmed/28426696 http://dx.doi.org/10.1371/journal.pone.0175800 |
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