Mini-G proteins: Novel tools for studying GPCRs in their active conformation

Mini-G proteins are the engineered GTPase domains of Gα subunits. They couple to GPCRs and recapitulate the increase in agonist affinity observed upon coupling of a native heterotrimeric G protein. Given the small size and stability of mini-G proteins, and their ease of expression and purification,...

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Detalles Bibliográficos
Autores principales: Nehmé, Rony, Carpenter, Byron, Singhal, Ankita, Strege, Annette, Edwards, Patricia C., White, Courtney F., Du, Haijuan, Grisshammer, Reinhard, Tate, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398546/
https://www.ncbi.nlm.nih.gov/pubmed/28426733
http://dx.doi.org/10.1371/journal.pone.0175642

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