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Regulation of SESAME-mediated H3T11 phosphorylation by glycolytic enzymes and metabolites

Cancer cells prefer aerobic glycolysis, but little is known about the underlying mechanism. Recent studies showed that the rate-limiting glycolytic enzymes, pyruvate kinase M2 (PKM2) directly phosphorylates H3 at threonine 11 (H3T11) to regulate gene expression and cell proliferation, revealing its...

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Detalles Bibliográficos
Autores principales:	Yu, Qi, Tong, Chong, Luo, Mingdan, Xue, Xiangyan, Mei, Qianyun, Ma, Lixin, Yu, Xiaolan, Mao, Wuxiang, Kong, Lingbao, Yu, Xilan, Li, Shanshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398556/ https://www.ncbi.nlm.nih.gov/pubmed/28426732 http://dx.doi.org/10.1371/journal.pone.0175576

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