Cargando…

Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle

The growth and maturity of cattle body size affect not only feed efficiency, but also productivity and longevity. Dissecting the genetic architecture of body size is critical for cattle breeding to improve both efficiency and productivity. The volume and weight of body size are indicated by several...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xu, Chu, Qin, Guo, Gang, Dong, Ganghui, Li, Xizhi, Zhang, Qin, Zhang, Shengli, Zhang, Zhiwu, Wang, Yachun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398616/
https://www.ncbi.nlm.nih.gov/pubmed/28426785
http://dx.doi.org/10.1371/journal.pone.0175971
_version_ 1783230495138512896
author Zhang, Xu
Chu, Qin
Guo, Gang
Dong, Ganghui
Li, Xizhi
Zhang, Qin
Zhang, Shengli
Zhang, Zhiwu
Wang, Yachun
author_facet Zhang, Xu
Chu, Qin
Guo, Gang
Dong, Ganghui
Li, Xizhi
Zhang, Qin
Zhang, Shengli
Zhang, Zhiwu
Wang, Yachun
author_sort Zhang, Xu
collection PubMed
description The growth and maturity of cattle body size affect not only feed efficiency, but also productivity and longevity. Dissecting the genetic architecture of body size is critical for cattle breeding to improve both efficiency and productivity. The volume and weight of body size are indicated by several measurements. Among them, Heart Girth (HG) and Hip Height (HH) are the most important traits. They are widely used as predictors of body weight (BW). Few association studies have been conducted for HG and HH in cattle focusing on single growth stage. In this study, we extended the Genome-wide association studies to a full spectrum of four growth stages (6-, 12-, 18-, and 24-months after birth) in Chinese Holstein heifers. The whole genomic single nucleotide polymorphisms (SNPs) were obtained from the Illumina BovineSNP50 v2 BeadChip genotyped on 3,325 individuals. Estimated breeding values (EBVs) were derived for both HG and HH at the four different ages and analyzed separately for GWAS by using the Fixed and random model Circuitous Probability Unification (FarmCPU) method. In total, 27 SNPs were identified to be significantly associated with HG and HH at different growth stages. We found 66 candidate genes located nearby the associated SNPs, including nine genes that were known as highly related to development and skeletal and muscular growth. In addition, biological function analysis was performed by Ingenuity Pathway Analysis and an interaction network related to development was obtained, which contained 16 genes out of the 66 candidates. The set of putative genes provided valuable resources and can help elucidate the genomic architecture and mechanisms underlying growth traits in dairy cattle.
format Online
Article
Text
id pubmed-5398616
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-53986162017-05-04 Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle Zhang, Xu Chu, Qin Guo, Gang Dong, Ganghui Li, Xizhi Zhang, Qin Zhang, Shengli Zhang, Zhiwu Wang, Yachun PLoS One Research Article The growth and maturity of cattle body size affect not only feed efficiency, but also productivity and longevity. Dissecting the genetic architecture of body size is critical for cattle breeding to improve both efficiency and productivity. The volume and weight of body size are indicated by several measurements. Among them, Heart Girth (HG) and Hip Height (HH) are the most important traits. They are widely used as predictors of body weight (BW). Few association studies have been conducted for HG and HH in cattle focusing on single growth stage. In this study, we extended the Genome-wide association studies to a full spectrum of four growth stages (6-, 12-, 18-, and 24-months after birth) in Chinese Holstein heifers. The whole genomic single nucleotide polymorphisms (SNPs) were obtained from the Illumina BovineSNP50 v2 BeadChip genotyped on 3,325 individuals. Estimated breeding values (EBVs) were derived for both HG and HH at the four different ages and analyzed separately for GWAS by using the Fixed and random model Circuitous Probability Unification (FarmCPU) method. In total, 27 SNPs were identified to be significantly associated with HG and HH at different growth stages. We found 66 candidate genes located nearby the associated SNPs, including nine genes that were known as highly related to development and skeletal and muscular growth. In addition, biological function analysis was performed by Ingenuity Pathway Analysis and an interaction network related to development was obtained, which contained 16 genes out of the 66 candidates. The set of putative genes provided valuable resources and can help elucidate the genomic architecture and mechanisms underlying growth traits in dairy cattle. Public Library of Science 2017-04-20 /pmc/articles/PMC5398616/ /pubmed/28426785 http://dx.doi.org/10.1371/journal.pone.0175971 Text en © 2017 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhang, Xu
Chu, Qin
Guo, Gang
Dong, Ganghui
Li, Xizhi
Zhang, Qin
Zhang, Shengli
Zhang, Zhiwu
Wang, Yachun
Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle
title Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle
title_full Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle
title_fullStr Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle
title_full_unstemmed Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle
title_short Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle
title_sort genome-wide association studies identified multiple genetic loci for body size at four growth stages in chinese holstein cattle
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398616/
https://www.ncbi.nlm.nih.gov/pubmed/28426785
http://dx.doi.org/10.1371/journal.pone.0175971
work_keys_str_mv AT zhangxu genomewideassociationstudiesidentifiedmultiplegeneticlociforbodysizeatfourgrowthstagesinchineseholsteincattle
AT chuqin genomewideassociationstudiesidentifiedmultiplegeneticlociforbodysizeatfourgrowthstagesinchineseholsteincattle
AT guogang genomewideassociationstudiesidentifiedmultiplegeneticlociforbodysizeatfourgrowthstagesinchineseholsteincattle
AT dongganghui genomewideassociationstudiesidentifiedmultiplegeneticlociforbodysizeatfourgrowthstagesinchineseholsteincattle
AT lixizhi genomewideassociationstudiesidentifiedmultiplegeneticlociforbodysizeatfourgrowthstagesinchineseholsteincattle
AT zhangqin genomewideassociationstudiesidentifiedmultiplegeneticlociforbodysizeatfourgrowthstagesinchineseholsteincattle
AT zhangshengli genomewideassociationstudiesidentifiedmultiplegeneticlociforbodysizeatfourgrowthstagesinchineseholsteincattle
AT zhangzhiwu genomewideassociationstudiesidentifiedmultiplegeneticlociforbodysizeatfourgrowthstagesinchineseholsteincattle
AT wangyachun genomewideassociationstudiesidentifiedmultiplegeneticlociforbodysizeatfourgrowthstagesinchineseholsteincattle