Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7

PURPOSE: To examine the effects of autophagy deficiency induced by RPE-specific deletion of Atg5 or Atg7 in mice as a function of age. METHODS: Conditional knockout mice with a floxed allele of Atg5 or Atg7 were crossed with inducible VMD2-rtTA/Cre transgenic mice. VMD2-directed RPE-specific Cre rec...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Youwen, Cross, Samuel D., Stanton, James B., Marmorstein, Alan D., Le, Yun Zheng, Marmorstein, Lihua Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398883/
https://www.ncbi.nlm.nih.gov/pubmed/28465655

Ejemplares similares

Ejemplares similares