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Identification of a pre-active conformation of a pentameric channel receptor

Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical signaling through global allosteric transitions. Despite the existence of several high-resolution structures of pLGICs, their dynamical properties remain elusive. Using the proton-gated channel GLIC, we engineered multiple fluoresce...

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Detalles Bibliográficos
Autores principales:	Menny, Anaïs, Lefebvre, Solène N, Schmidpeter, Philipp AM, Drège, Emmanuelle, Fourati, Zaineb, Delarue, Marc, Edelstein, Stuart J, Nimigean, Crina M, Joseph, Delphine, Corringer, Pierre-Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398890/ https://www.ncbi.nlm.nih.gov/pubmed/28294942 http://dx.doi.org/10.7554/eLife.23955

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