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Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer
Approximately 75% of breast cancers express estrogen receptor α (ERα) and depend on estrogen signals for continued growth. Aromatase inhibitors (AIs) prevent estrogen production and inhibit estrogen receptor signaling, resulting in decreased cancer recurrence and mortality. Advanced tumors treated w...
Autores principales: | Hiken, Jeffrey F., McDonald, James I., Decker, Keith F., Sanchez, Cesar, Hoog, Jeremy, VanderKraats, Nathan D., Jung, Kyle L., Akinhanmi, Margaret, Rois, Lisa E., Ellis, Matthew J., Edwards, John R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398938/ https://www.ncbi.nlm.nih.gov/pubmed/27869171 http://dx.doi.org/10.1038/onc.2016.397 |
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