Attempting to Compensate for Reduced Neuronal Nitric Oxide Synthase Protein with Nitrate Supplementation Cannot Overcome Metabolic Dysfunction but Rather Has Detrimental Effects in Dystrophin-Deficient mdx Muscle

Duchenne muscular dystrophy arises from the loss of dystrophin and is characterized by calcium dysregulation, muscular atrophy, and metabolic dysfunction. The secondary reduction of neuronal nitric oxide synthase (nNOS) from the sarcolemma reduces NO production and bioavailability. As NO modulates g...

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Detalles Bibliográficos
Autores principales: Timpani, Cara A., Trewin, Adam J., Stojanovska, Vanesa, Robinson, Ainsley, Goodman, Craig A., Nurgali, Kulmira, Betik, Andrew C., Stepto, Nigel, Hayes, Alan, McConell, Glenn K., Rybalka, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398978/
https://www.ncbi.nlm.nih.gov/pubmed/27921261
http://dx.doi.org/10.1007/s13311-016-0494-7

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