Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration

Abnormal cytoplasmic mislocalization of transactive response DNA binding protein 43 (TARDBP or TDP-43) in degenerating neurons is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). Our previous work suggested that nucl...

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Detalles Bibliográficos
Autores principales: Dutta, Kallol, Patel, Priyanka, Rahimian, Reza, Phaneuf, Daniel, Julien, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398980/
https://www.ncbi.nlm.nih.gov/pubmed/27928708
http://dx.doi.org/10.1007/s13311-016-0499-2

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