Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment

There is increasing interest in the use of quantitative transcriptomic data to determine benchmark dose (BMD) and estimate a point of departure (POD) for human health risk assessment. Although studies have shown that transcriptional PODs correlate with those derived from apical endpoint changes, the...

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Detalles Bibliográficos
Autores principales: Farmahin, Reza, Williams, Andrew, Kuo, Byron, Chepelev, Nikolai L., Thomas, Russell S., Barton-Maclaren, Tara S., Curran, Ivan H., Nong, Andy, Wade, Michael G., Yauk, Carole L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Regulatory Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399047/
https://www.ncbi.nlm.nih.gov/pubmed/27928627
http://dx.doi.org/10.1007/s00204-016-1886-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399047/
https://www.ncbi.nlm.nih.gov/pubmed/27928627
http://dx.doi.org/10.1007/s00204-016-1886-5

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