Cargando…
Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML
Therapy directed against oncogenic FLT3 has been shown to induce response in patients with acute myeloid leukemia (AML), but these responses are almost always transient. To address the mechanism of FLT3 inhibitor resistance, we generated two resistant AML cell lines by sustained treatment with the F...
Autores principales: | Lindblad, O, Cordero, E, Puissant, A, Macaulay, L, Ramos, A, Kabir, N N, Sun, J, Vallon-Christersson, J, Haraldsson, K, Hemann, M T, Borg, Å, Levander, F, Stegmaier, K, Pietras, K, Rönnstrand, L, Kazi, J U |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399143/ https://www.ncbi.nlm.nih.gov/pubmed/26999641 http://dx.doi.org/10.1038/onc.2016.41 |
Ejemplares similares
-
BEX1 acts as a tumor suppressor in acute myeloid leukemia
por: Lindblad, Oscar, et al.
Publicado: (2015) -
SYK Regulates mTOR Signaling in AML
por: Carnevale, Julia, et al.
Publicado: (2013) -
Expression of GADS enhances FLT3-induced mitogenic signaling
por: Chougule, Rohit A., et al.
Publicado: (2016) -
The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia
por: Moharram, Sausan A., et al.
Publicado: (2019) -
Correction: The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia
por: Moharram, Sausan A., et al.
Publicado: (2019)