A model to predict anti-tuberculosis activity: value proposition for marine microorganisms

The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed...

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Detalles Bibliográficos
Autores principales: Liu, Miaomiao, Grkovic, Tanja, Zhang, Lixin, Liu, Xueting, Quinn, Ronald J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399163/
https://www.ncbi.nlm.nih.gov/pubmed/27406906
http://dx.doi.org/10.1038/ja.2016.87
Descripción
Sumario:The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed mycobacteria-active natural products. We showed that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space. A model to predict potential anti-TB drugs is proposed.

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