Low nanomolar concentrations of Cucurbitacin-I induces G2/M phase arrest and apoptosis by perturbing redox homeostasis in gastric cancer cells in vitro and in vivo

Cucurbitacin-I (Cu-I, also known as Elatericin B or JSI-124) is developed to inhibit constitutive and abnormal activation of STAT3 in many cancers, demonstrating a potent anticancer activity by targeting disruption of STAT3 function. Here, we for the first time systematically studied the underlying...

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Detalles Bibliográficos
Autores principales: Deng, C, Zhang, B, Zhang, S, Duan, C, Cao, Y, Kang, W, Yan, H, Ding, X, Zhou, F, Wu, L, Duan, G, Shen, S, Xu, G, Zhang, W, Chen, M, Huang, S, Zhang, X, Lv, Y, Ling, T, Wang, L, Zou, X
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399186/
https://www.ncbi.nlm.nih.gov/pubmed/26890145
http://dx.doi.org/10.1038/cddis.2016.13

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