Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa

Although patients with anorexia nervosa (anorexia) are known to show tubulointerstitial nephritis (TIN), the pathophysiology of its progression is not fully understood. We herein report a 31-year-old woman with anorexia who showed acute exacerbation of chronic kidney disease. Renal biopsy showed non...

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Autores principales: Hasegawa, Sho, Shibata, Maki, Mochizuki, Makoto, Katsuki, Takashi, Tada, Manami, Hinoshita, Fumihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399208/
https://www.ncbi.nlm.nih.gov/pubmed/28250303
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author Hasegawa, Sho
Shibata, Maki
Mochizuki, Makoto
Katsuki, Takashi
Tada, Manami
Hinoshita, Fumihiko
author_facet Hasegawa, Sho
Shibata, Maki
Mochizuki, Makoto
Katsuki, Takashi
Tada, Manami
Hinoshita, Fumihiko
author_sort Hasegawa, Sho
collection PubMed
description Although patients with anorexia nervosa (anorexia) are known to show tubulointerstitial nephritis (TIN), the pathophysiology of its progression is not fully understood. We herein report a 31-year-old woman with anorexia who showed acute exacerbation of chronic kidney disease. Renal biopsy showed non-uniform chronic TIN; some areas were obsolete lesions and other areas were active lesions. In addition, many calcium-containing crystals were widely deposited in the distal tubules. The results suggest that chronic TIN in the setting of anorexia does not uniformly progress and that not only TIN but also widespread calcification of distal tubules might aggravate the renal function of anorexia patients.
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spelling pubmed-53992082017-04-24 Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa Hasegawa, Sho Shibata, Maki Mochizuki, Makoto Katsuki, Takashi Tada, Manami Hinoshita, Fumihiko Intern Med Case Report Although patients with anorexia nervosa (anorexia) are known to show tubulointerstitial nephritis (TIN), the pathophysiology of its progression is not fully understood. We herein report a 31-year-old woman with anorexia who showed acute exacerbation of chronic kidney disease. Renal biopsy showed non-uniform chronic TIN; some areas were obsolete lesions and other areas were active lesions. In addition, many calcium-containing crystals were widely deposited in the distal tubules. The results suggest that chronic TIN in the setting of anorexia does not uniformly progress and that not only TIN but also widespread calcification of distal tubules might aggravate the renal function of anorexia patients. The Japanese Society of Internal Medicine 2017-03-01 /pmc/articles/PMC5399208/ /pubmed/28250303 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hasegawa, Sho
Shibata, Maki
Mochizuki, Makoto
Katsuki, Takashi
Tada, Manami
Hinoshita, Fumihiko
Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa
title Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa
title_full Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa
title_fullStr Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa
title_full_unstemmed Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa
title_short Non-uniform Progression of Chronic Tubulointerstitial Nephritis and Widespread Nephrocalcification in a Patient with Anorexia Nervosa
title_sort non-uniform progression of chronic tubulointerstitial nephritis and widespread nephrocalcification in a patient with anorexia nervosa
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399208/
https://www.ncbi.nlm.nih.gov/pubmed/28250303
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