Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution

Abnormal axonal transport is associated with neuronal disease. We identified a role for DHC-1, the C. elegans dynein heavy chain, in maintaining neuronal cargo distribution. Surprisingly, this does not involve dynein's role as a retrograde motor in cargo transport, hinging instead on its abilit...

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Detalles Bibliográficos
Autores principales: Yogev, Shaul, Maeder, Celine I., Cooper, Roshni, Horowitz, Mark, Hendricks, Adam G., Shen, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399302/
https://www.ncbi.nlm.nih.gov/pubmed/28406181
http://dx.doi.org/10.1038/ncomms15063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399302/
https://www.ncbi.nlm.nih.gov/pubmed/28406181
http://dx.doi.org/10.1038/ncomms15063

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