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Monitoring mandibular movements to detect Cheyne-Stokes Breathing

BACKGROUND: The patterns of mandibular movements (MM) during sleep can be used to identify increased respiratory effort periodic large-amplitude MM (LPM), and cortical arousals associated with “sharp” large-amplitude MM (SPM). We hypothesized that Cheyne Stokes breathing (CSB) may be identified by p...

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Autores principales: Martinot, Jean-Benoît, Borel, Jean-Christian, Le-Dong, Nhat-Nam, Guénard, Hervé Jean-Pierre, Cuthbert, Valerie, Silkoff, Philip E., Gozal, David, Pepin, Jean-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399309/
https://www.ncbi.nlm.nih.gov/pubmed/28427400
http://dx.doi.org/10.1186/s12931-017-0551-8
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author Martinot, Jean-Benoît
Borel, Jean-Christian
Le-Dong, Nhat-Nam
Guénard, Hervé Jean-Pierre
Cuthbert, Valerie
Silkoff, Philip E.
Gozal, David
Pepin, Jean-Louis
author_facet Martinot, Jean-Benoît
Borel, Jean-Christian
Le-Dong, Nhat-Nam
Guénard, Hervé Jean-Pierre
Cuthbert, Valerie
Silkoff, Philip E.
Gozal, David
Pepin, Jean-Louis
author_sort Martinot, Jean-Benoît
collection PubMed
description BACKGROUND: The patterns of mandibular movements (MM) during sleep can be used to identify increased respiratory effort periodic large-amplitude MM (LPM), and cortical arousals associated with “sharp” large-amplitude MM (SPM). We hypothesized that Cheyne Stokes breathing (CSB) may be identified by periodic abnormal MM patterns. The present study aims to evaluate prospectively the concordance between CSB detected by periodic MM and polysomnography (PSG) as gold-standard. The present study aims to evaluate prospectively the concordance between CSB detected by periodic MM and polysomnography (PSG) as gold-standard. METHODS: In 573 consecutive patients attending an in-laboratory PSG for suspected sleep disordered breathing (SDB), MM signals were acquired using magnetometry and scored manually while blinded from the PSG signal. Data analysis aimed to verify the concordance between the CSB identified by PSG and the presence of LPM or SPM. The data were randomly divided into training and validation sets (985 5-min segments/set) and concordance was evaluated using 2 classification models. RESULTS: In PSG, 22 patients (mean age ± SD: 65.9 ± 15.0 with a sex ratio M/F of 17/5) had CSB (mean central apnea hourly indice ± SD: 17.5 ± 6.2) from a total of 573 patients with suspected SDB. When tested on independent subset, the classification of CSB based on LPM and SPM is highly accurate (Balanced-accuracy = 0.922, sensitivity = 0.922, specificity = 0.921 and error-rate = 0.078). Logistic models based odds-ratios for CSB in presence of SPM or LPM were 172.43 (95% CI: 88.23–365.04; p < 0.001) and 186.79 (95% CI: 100.48–379.93; p < 0.001), respectively. CONCLUSION: CSB in patients with sleep disordered breathing could be accurately identified by a simple magnetometer device recording mandibular movements.
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spelling pubmed-53993092017-04-24 Monitoring mandibular movements to detect Cheyne-Stokes Breathing Martinot, Jean-Benoît Borel, Jean-Christian Le-Dong, Nhat-Nam Guénard, Hervé Jean-Pierre Cuthbert, Valerie Silkoff, Philip E. Gozal, David Pepin, Jean-Louis Respir Res Research BACKGROUND: The patterns of mandibular movements (MM) during sleep can be used to identify increased respiratory effort periodic large-amplitude MM (LPM), and cortical arousals associated with “sharp” large-amplitude MM (SPM). We hypothesized that Cheyne Stokes breathing (CSB) may be identified by periodic abnormal MM patterns. The present study aims to evaluate prospectively the concordance between CSB detected by periodic MM and polysomnography (PSG) as gold-standard. The present study aims to evaluate prospectively the concordance between CSB detected by periodic MM and polysomnography (PSG) as gold-standard. METHODS: In 573 consecutive patients attending an in-laboratory PSG for suspected sleep disordered breathing (SDB), MM signals were acquired using magnetometry and scored manually while blinded from the PSG signal. Data analysis aimed to verify the concordance between the CSB identified by PSG and the presence of LPM or SPM. The data were randomly divided into training and validation sets (985 5-min segments/set) and concordance was evaluated using 2 classification models. RESULTS: In PSG, 22 patients (mean age ± SD: 65.9 ± 15.0 with a sex ratio M/F of 17/5) had CSB (mean central apnea hourly indice ± SD: 17.5 ± 6.2) from a total of 573 patients with suspected SDB. When tested on independent subset, the classification of CSB based on LPM and SPM is highly accurate (Balanced-accuracy = 0.922, sensitivity = 0.922, specificity = 0.921 and error-rate = 0.078). Logistic models based odds-ratios for CSB in presence of SPM or LPM were 172.43 (95% CI: 88.23–365.04; p < 0.001) and 186.79 (95% CI: 100.48–379.93; p < 0.001), respectively. CONCLUSION: CSB in patients with sleep disordered breathing could be accurately identified by a simple magnetometer device recording mandibular movements. BioMed Central 2017-04-20 2017 /pmc/articles/PMC5399309/ /pubmed/28427400 http://dx.doi.org/10.1186/s12931-017-0551-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Martinot, Jean-Benoît
Borel, Jean-Christian
Le-Dong, Nhat-Nam
Guénard, Hervé Jean-Pierre
Cuthbert, Valerie
Silkoff, Philip E.
Gozal, David
Pepin, Jean-Louis
Monitoring mandibular movements to detect Cheyne-Stokes Breathing
title Monitoring mandibular movements to detect Cheyne-Stokes Breathing
title_full Monitoring mandibular movements to detect Cheyne-Stokes Breathing
title_fullStr Monitoring mandibular movements to detect Cheyne-Stokes Breathing
title_full_unstemmed Monitoring mandibular movements to detect Cheyne-Stokes Breathing
title_short Monitoring mandibular movements to detect Cheyne-Stokes Breathing
title_sort monitoring mandibular movements to detect cheyne-stokes breathing
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399309/
https://www.ncbi.nlm.nih.gov/pubmed/28427400
http://dx.doi.org/10.1186/s12931-017-0551-8
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