Cargando…

Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study

BACKGROUND: Kidney disease improving global outcomes provided a new classification for chronic kidney disease (CKD) by subdividing the G3 stage into G3a and G3b stages based on glomerular filtration rate (GFR) in 2012. Currently, a few methods are used to evaluate GFR, including measured GFR (mGFR)...

Descripción completa

Detalles Bibliográficos
Autores principales: Dou, Yanna, Sun, Xiran, Liu, Dong, Zhang, Li, Xiao, Jing, Cheng, Genyang, Yu, Dahai, Zhao, Zhanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399329/
https://www.ncbi.nlm.nih.gov/pubmed/28235417
http://dx.doi.org/10.1186/s13104-017-2400-8
_version_ 1783230620044886016
author Dou, Yanna
Sun, Xiran
Liu, Dong
Zhang, Li
Xiao, Jing
Cheng, Genyang
Yu, Dahai
Zhao, Zhanzheng
author_facet Dou, Yanna
Sun, Xiran
Liu, Dong
Zhang, Li
Xiao, Jing
Cheng, Genyang
Yu, Dahai
Zhao, Zhanzheng
author_sort Dou, Yanna
collection PubMed
description BACKGROUND: Kidney disease improving global outcomes provided a new classification for chronic kidney disease (CKD) by subdividing the G3 stage into G3a and G3b stages based on glomerular filtration rate (GFR) in 2012. Currently, a few methods are used to evaluate GFR, including measured GFR (mGFR) and estimated GFR (eGFR). One of the mGFR was (99m)Tc-DTPA scintigraphy method and eGFR using GFR equations were used clinically. Equations were modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), and Chinese adapted MDRD (C-MDRD). This study assessed the accuracy of three different equations for estimated glomerular filtration rate (eGFR) with mGFR using DTPA scintigraphy method as the standard in a population of Chinese chronic kidney disease patients at the G3a stage. RESULTS: One hundred and twenty-two patients (age 52.0 ± 15.6 years, 69 were male) were determined as CKD stage 3 based on mGFR. Patients were divided into G3a (47 patients) and G3b (75 patients) subgroups. Bias between eGFR for CKD-EPI and reference mGFR was 0.92 mL/min and 95% limits of agreement was −38.82 to 40.67 mL/min. Bias between eGFR for C-MDRD and mGFR was 3.76 and 95% limits of agreement was −39.32 to 46.85 mL/min. Bias between eGFR for MDRD and mGFR was 3.53 and 95% limits of agreement was −43.35 to 50.4 mL/min. The CKD-EPI equation showed better diagnostic value with a greater area under the receiver operating characteristic curve (AUC: 0.763). AUC for MDRD and C-MDRD were 0.75 and 0.757, respectively. CONCLUSIONS: There were no obvious advantages in accuracy, sensitivity, and specificity for the diagnosis of patients at the G3a stage using the CKD-EPI equation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13104-017-2400-8) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-5399329
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-53993292017-04-24 Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study Dou, Yanna Sun, Xiran Liu, Dong Zhang, Li Xiao, Jing Cheng, Genyang Yu, Dahai Zhao, Zhanzheng BMC Res Notes Research Article BACKGROUND: Kidney disease improving global outcomes provided a new classification for chronic kidney disease (CKD) by subdividing the G3 stage into G3a and G3b stages based on glomerular filtration rate (GFR) in 2012. Currently, a few methods are used to evaluate GFR, including measured GFR (mGFR) and estimated GFR (eGFR). One of the mGFR was (99m)Tc-DTPA scintigraphy method and eGFR using GFR equations were used clinically. Equations were modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), and Chinese adapted MDRD (C-MDRD). This study assessed the accuracy of three different equations for estimated glomerular filtration rate (eGFR) with mGFR using DTPA scintigraphy method as the standard in a population of Chinese chronic kidney disease patients at the G3a stage. RESULTS: One hundred and twenty-two patients (age 52.0 ± 15.6 years, 69 were male) were determined as CKD stage 3 based on mGFR. Patients were divided into G3a (47 patients) and G3b (75 patients) subgroups. Bias between eGFR for CKD-EPI and reference mGFR was 0.92 mL/min and 95% limits of agreement was −38.82 to 40.67 mL/min. Bias between eGFR for C-MDRD and mGFR was 3.76 and 95% limits of agreement was −39.32 to 46.85 mL/min. Bias between eGFR for MDRD and mGFR was 3.53 and 95% limits of agreement was −43.35 to 50.4 mL/min. The CKD-EPI equation showed better diagnostic value with a greater area under the receiver operating characteristic curve (AUC: 0.763). AUC for MDRD and C-MDRD were 0.75 and 0.757, respectively. CONCLUSIONS: There were no obvious advantages in accuracy, sensitivity, and specificity for the diagnosis of patients at the G3a stage using the CKD-EPI equation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13104-017-2400-8) contains supplementary material, which is available to authorized users. BioMed Central 2017-02-24 /pmc/articles/PMC5399329/ /pubmed/28235417 http://dx.doi.org/10.1186/s13104-017-2400-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Dou, Yanna
Sun, Xiran
Liu, Dong
Zhang, Li
Xiao, Jing
Cheng, Genyang
Yu, Dahai
Zhao, Zhanzheng
Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study
title Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study
title_full Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study
title_fullStr Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study
title_full_unstemmed Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study
title_short Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study
title_sort accuracy of glomerular filtration rate equations for chronic kidney disease patients at the g3a stage: a single-center cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399329/
https://www.ncbi.nlm.nih.gov/pubmed/28235417
http://dx.doi.org/10.1186/s13104-017-2400-8
work_keys_str_mv AT douyanna accuracyofglomerularfiltrationrateequationsforchronickidneydiseasepatientsattheg3astageasinglecentercrosssectionalstudy
AT sunxiran accuracyofglomerularfiltrationrateequationsforchronickidneydiseasepatientsattheg3astageasinglecentercrosssectionalstudy
AT liudong accuracyofglomerularfiltrationrateequationsforchronickidneydiseasepatientsattheg3astageasinglecentercrosssectionalstudy
AT zhangli accuracyofglomerularfiltrationrateequationsforchronickidneydiseasepatientsattheg3astageasinglecentercrosssectionalstudy
AT xiaojing accuracyofglomerularfiltrationrateequationsforchronickidneydiseasepatientsattheg3astageasinglecentercrosssectionalstudy
AT chenggenyang accuracyofglomerularfiltrationrateequationsforchronickidneydiseasepatientsattheg3astageasinglecentercrosssectionalstudy
AT yudahai accuracyofglomerularfiltrationrateequationsforchronickidneydiseasepatientsattheg3astageasinglecentercrosssectionalstudy
AT zhaozhanzheng accuracyofglomerularfiltrationrateequationsforchronickidneydiseasepatientsattheg3astageasinglecentercrosssectionalstudy