Cargando…

Novel SUMO-Protease SENP7S Regulates β-catenin Signaling and Mammary Epithelial Cell Transformation

SUMO post-translational modification of proteins or SUMOylation ensures normal cell function. Disruption of SUMO dynamics prompts various pathophysiological conditions, including cancer. The burden of deSUMOylating the large SUMO-proteome rests on 6 full-length mammalian SUMO-proteases or SENP. Whil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karami, Samaneh, Lin, Feng-Ming, Kumar, Santosh, Bahnassy, Shaymaa, Thangavel, Hariprasad, Quttina, Maram, Li, Yue, Ren, Jing, Bawa-Khalfe, Tasneem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399363/ https://www.ncbi.nlm.nih.gov/pubmed/28429743 http://dx.doi.org/10.1038/srep46477

Ejemplares similares

Constitutively active androgen receptor supports the metastatic phenotype of endocrine-resistant hormone receptor-positive breast cancer
por: Bahnassy, Shaymaa, et al.
Publicado: (2020)

Exosc9 Initiates SUMO-Dependent lncRNA TERRA Degradation to Impact Telomeric Integrity in Endocrine Therapy Insensitive Hormone Receptor-Positive Breast Cancer
por: Quttina, Maram, et al.
Publicado: (2023)

SUMOylation of HP1α supports association with ncRNA to define responsiveness of breast cancer cells to chemotherapy
por: Lin, Feng-Ming, et al.
Publicado: (2016)

SUMO-specific proteases/isopeptidases: SENPs and beyond
por: Nayak, Arnab, et al.
Publicado: (2014)

Advances in the development of SUMO specific protease (SENP) inhibitors
por: Kumar, Ashutosh, et al.
Publicado: (2015)

Genetic Polymorphism of SUMO-Specific Cysteine Proteases − SENP1 and SENP2 in Breast Cancer
por: Mirecka, Alicja, et al.
Publicado: (2016)

The SUMO protease SENP6 is essential for inner kinetochore assembly
por: Mukhopadhyay, Debaditya, et al.
Publicado: (2010)

The Leishmania donovani SENP Protease Is Required for SUMO Processing but Not for Viability
por: Bea, Annika, et al.
Publicado: (2020)

Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs)
por: Jia, Yuqing, et al.
Publicado: (2019)

Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2
por: Chow, Kin-Hoe, et al.
Publicado: (2012)

Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells
por: Federzoni, Elena A., et al.
Publicado: (2015)

SENP1 regulates PTEN stability to dictate prostate cancer development
por: Bawa-Khalfe, Tasneem, et al.
Publicado: (2016)

Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases
por: Yun, Chawon, et al.
Publicado: (2008)

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies
por: Hattersley, Neil, et al.
Publicado: (2011)

The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1
por: Waters, Emily, et al.
Publicado: (2022)

The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function
por: Chow, Kin-Hoe, et al.
Publicado: (2014)

The Critical Roles of the SUMO-Specific Protease SENP3 in Human Diseases and Clinical Implications
por: Long, Xiaojun, et al.
Publicado: (2020)

TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity
por: Li, Yun-Yi, et al.
Publicado: (2022)

SENP6 cuts SUMOs down to size
por: Leslie, Mitch
Publicado: (2010)

Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90
por: Yan, Shan, et al.
Publicado: (2010)

MYB regulates the SUMO protease SENP1 and its novel interaction partner UXT, modulating MYB target genes and the SUMO landscape
por: Lemma, Roza Berhanu, et al.
Publicado: (2023)

Conformational flexibility and changes underlying activation of the SUMO-specific protease SENP1 by remote substrate binding
por: Chen, Chih-Hong, et al.
Publicado: (2014)

SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle
por: Koo, Young Do, et al.
Publicado: (2015)

The SUMO Protease SENP3 Orchestrates G2-M Transition and Spindle Assembly in Mouse Oocytes
por: Huang, Chun-Jie, et al.
Publicado: (2015)

The Epstein-Barr Virus Oncoprotein, LMP1, Regulates the Function of SENP2, a SUMO-protease
por: Selby, Thomas L., et al.
Publicado: (2019)

The ERβ4 variant induces transformation of the normal breast mammary epithelial cell line MCF-10A; the ERβ variants ERβ2 and ERβ5 increase aggressiveness of TNBC by regulation of hypoxic signaling
por: Faria, Michelle, et al.
Publicado: (2018)

The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation
por: Liebelt, Frauke, et al.
Publicado: (2019)

The SUMO protease SENP1 promotes aggressive behaviors of high HIF2α expressing renal cell carcinoma cells
por: Lee, Moon Hee, et al.
Publicado: (2022)

Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6
por: Liu, Xing, et al.
Publicado: (2013)

The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development
por: Yu, H‐M Ivy, et al.
Publicado: (2019)

DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages
por: Lao, Yimin, et al.
Publicado: (2018)

The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels
por: Chen, Xu, et al.
Publicado: (2021)

SENP Proteases as Potential Targets for Cancer Therapy
por: Tokarz, Paulina, et al.
Publicado: (2021)

Sumo-dependent substrate targeting of the SUMO protease Ulp1
por: Elmore, Zachary C, et al.
Publicado: (2011)

SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing
por: Cui, Ye, et al.
Publicado: (2017)

Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes
por: Nayak, Arnab, et al.
Publicado: (2017)

Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases
por: Mulder, Monique P. C., et al.
Publicado: (2018)

SUMO targeting of a stress-tolerant Ulp1 SUMO protease
por: Peek, Jennifer, et al.
Publicado: (2018)

Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism
por: Guo, Jingjing, et al.
Publicado: (2016)

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma
por: Schick, Markus, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i17tbbu39hjni5npc6k4c5csfs