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Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

BACKGROUND AND AIMS: Malignant melanoma is an aggressive tumor sensitive for immunotherapy such as checkpoint blockade antibodies. Still, most patients with late stage disease do not respond, and the side effects can be severe. Stimulation of the CD40 pathway to initiate anti-tumor immunity is a pro...

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Detalles Bibliográficos
Autores principales:	Schiza, A., Wenthe, J., Mangsbo, S., Eriksson, E., Nilsson, Anders, Tötterman, T. H., Loskog, A., Ullenhag, G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399418/ https://www.ncbi.nlm.nih.gov/pubmed/28427434 http://dx.doi.org/10.1186/s12967-017-1182-z

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