Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration

BACKGROUND: Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses, executing important physiological functions in the central nervous system. The...

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Detalles Bibliográficos
Autores principales: Li, Yuju, Peer, Justin, Zhao, Runze, Xu, Yinghua, Wu, Beiqing, Wang, Yi, Tian, Changhai, Huang, Yunlong, Zheng, Jialin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399437/
https://www.ncbi.nlm.nih.gov/pubmed/28439409
http://dx.doi.org/10.1186/s40035-017-0080-x

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