Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules

Animal cloning has been achieved in many species by transplanting differentiated cell nuclei to unfertilized oocytes. However, the low efficiencies of cloning have remained an unresolved issue. Here we find that the combination of two small molecules, trichostatin A (TSA) and vitamin C (VC), under c...

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Detalles Bibliográficos
Autores principales: Miyamoto, Kei, Tajima, Yosuke, Yoshida, Koki, Oikawa, Mami, Azuma, Rika, Allen, George E., Tsujikawa, Tomomi, Tsukaguchi, Tomomasa, Bradshaw, Charles R., Jullien, Jerome, Yamagata, Kazuo, Matsumoto, Kazuya, Anzai, Masayuki, Imai, Hiroshi, Gurdon, John B., Yamada, Masayasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399555/
https://www.ncbi.nlm.nih.gov/pubmed/28412714
http://dx.doi.org/10.1242/bio.023473

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