Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer

5-Fluorouracil (5-FU) combined with radiotherapy is a common treatment strategy to treat human cancers, but the underlying mechanisms of this combination treatment remain unclear. Here, we report that NAD(+)-dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due to 5-FU exposure r...

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Detalles Bibliográficos
Autores principales: Tang, Ming, Lu, Xiaopeng, Zhang, Chaohua, Du, Changzheng, Cao, Linlin, Hou, Tianyun, Li, Zhiming, Tu, Bo, Cao, Ziyang, Li, Yinglu, Chen, Yongcan, Jiang, Lu, Wang, Hui, Wang, Lina, Liu, Baohua, Xu, Xingzhi, Luo, Jianyuan, Wang, Jiadong, Gu, Jin, Wang, Haiying, Zhu, Wei-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399598/
https://www.ncbi.nlm.nih.gov/pubmed/28435470
http://dx.doi.org/10.7150/thno.18804

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