Correcting Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats With an SGLT2 Inhibitor Restores Glucose Effectiveness in the Liver and Reduces Insulin Resistance in Skeletal Muscle

Ten-week-old Zucker diabetic fatty (ZDF) rats at an early stage of diabetes embody metabolic characteristics of obese human patients with type 2 diabetes, such as severe insulin and glucose intolerance in muscle and the liver, excessive postprandial excursion of plasma glucose and insulin, and a los...

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Autores principales: O’Brien, Tracy P., Jenkins, Erin C., Estes, Shanea K., Castaneda, Antonio V., Ueta, Kiichiro, Farmer, Tiffany D., Puglisi, Allison E., Swift, Larry L., Printz, Richard L., Shiota, Masakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399614/
https://www.ncbi.nlm.nih.gov/pubmed/28246292
http://dx.doi.org/10.2337/db16-1410

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