Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset

Type 1 diabetes is characterized by the loss of insulin production caused by β-cell dysfunction and/or destruction. The hypothesis that β-cell loss occurs early during the prediabetic phase has recently been challenged. Here we show, for the first time in situ, that in pancreas sections from autoant...

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Detalles Bibliográficos
Autores principales: Rodriguez-Calvo, Teresa, Zapardiel-Gonzalo, Jose, Amirian, Natalie, Castillo, Ericka, Lajevardi, Yasaman, Krogvold, Lars, Dahl-Jørgensen, Knut, von Herrath, Matthias G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399615/
https://www.ncbi.nlm.nih.gov/pubmed/28137793
http://dx.doi.org/10.2337/db16-1343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399615/
https://www.ncbi.nlm.nih.gov/pubmed/28137793
http://dx.doi.org/10.2337/db16-1343

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