Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?

OBJECTIVE: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS: We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally...

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Detalles Bibliográficos
Autores principales: Ferrara, Christine Therese, Geyer, Susan Michelle, Liu, Yuk-Fun, Evans-Molina, Carmella, Libman, Ingrid M., Besser, Rachel, Becker, Dorothy J., Rodriguez, Henry, Moran, Antoinette, Gitelman, Stephen E., Redondo, Maria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Novel Communications in Diabetes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399656/
https://www.ncbi.nlm.nih.gov/pubmed/28202550
http://dx.doi.org/10.2337/dc16-2331
Descripción
Sumario:OBJECTIVE: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS: We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-specific ceBMI thresholds for greatest type 1 diabetes risk. RESULTS: Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males. CONCLUSIONS: Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.

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