Cargando…
Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells
Within the CNS nuclear factor-kappa B (NF-κB) transcription factors are involved in a wide range of functions both in homeostasis and in pathology. Over the years, our and other groups produced a vast array of information on the complex involvement of NF-κB proteins in different aspects of postnatal...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399701/ https://www.ncbi.nlm.nih.gov/pubmed/28469638 http://dx.doi.org/10.4103/1673-5374.202919 |
_version_ | 1783230690236563456 |
---|---|
author | Bortolotto, Valeria Grilli, Mariagrazia |
author_facet | Bortolotto, Valeria Grilli, Mariagrazia |
author_sort | Bortolotto, Valeria |
collection | PubMed |
description | Within the CNS nuclear factor-kappa B (NF-κB) transcription factors are involved in a wide range of functions both in homeostasis and in pathology. Over the years, our and other groups produced a vast array of information on the complex involvement of NF-κB proteins in different aspects of postnatal neurogenesis. In particular, several extracellular signals and membrane receptors have been identified as being able to affect neural progenitor cells (NPC) and their progeny via NF-κB activation. A crucial role in the regulation of neuronal fate specification in adult hippocampal NPC is played by the NF-κB p50 subunit. NF-κB p50KO mice display a remarkable reduction in adult hippocampal neurogenesis which correlates with a selective defect in hippocampal-dependent short-term memory. Moreover absence of NF-κB p50 can profoundly affect the in vitro proneurogenic response of adult hippocampal NPC (ahNPC) to several endogenous signals and drugs. Herein we briefly review the current knowledge on the pivotal role of NF-κB p50 in the regulation of adult hippocampal neurogenesis. In addition we discuss more recent data that further extend the relevance of NF-κB p50 to novel astroglia-derived signals which can influence neuronal specification of ahNPC and to astrocyte-NPC cross-talk. |
format | Online Article Text |
id | pubmed-5399701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-53997012017-05-03 Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells Bortolotto, Valeria Grilli, Mariagrazia Neural Regen Res Invited Review Within the CNS nuclear factor-kappa B (NF-κB) transcription factors are involved in a wide range of functions both in homeostasis and in pathology. Over the years, our and other groups produced a vast array of information on the complex involvement of NF-κB proteins in different aspects of postnatal neurogenesis. In particular, several extracellular signals and membrane receptors have been identified as being able to affect neural progenitor cells (NPC) and their progeny via NF-κB activation. A crucial role in the regulation of neuronal fate specification in adult hippocampal NPC is played by the NF-κB p50 subunit. NF-κB p50KO mice display a remarkable reduction in adult hippocampal neurogenesis which correlates with a selective defect in hippocampal-dependent short-term memory. Moreover absence of NF-κB p50 can profoundly affect the in vitro proneurogenic response of adult hippocampal NPC (ahNPC) to several endogenous signals and drugs. Herein we briefly review the current knowledge on the pivotal role of NF-κB p50 in the regulation of adult hippocampal neurogenesis. In addition we discuss more recent data that further extend the relevance of NF-κB p50 to novel astroglia-derived signals which can influence neuronal specification of ahNPC and to astrocyte-NPC cross-talk. Medknow Publications & Media Pvt Ltd 2017-03 /pmc/articles/PMC5399701/ /pubmed/28469638 http://dx.doi.org/10.4103/1673-5374.202919 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Invited Review Bortolotto, Valeria Grilli, Mariagrazia Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells |
title | Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells |
title_full | Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells |
title_fullStr | Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells |
title_full_unstemmed | Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells |
title_short | Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells |
title_sort | novel insights into the role of nf-κb p50 in astrocyte-mediated fate specification of adult neural progenitor cells |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399701/ https://www.ncbi.nlm.nih.gov/pubmed/28469638 http://dx.doi.org/10.4103/1673-5374.202919 |
work_keys_str_mv | AT bortolottovaleria novelinsightsintotheroleofnfkbp50inastrocytemediatedfatespecificationofadultneuralprogenitorcells AT grillimariagrazia novelinsightsintotheroleofnfkbp50inastrocytemediatedfatespecificationofadultneuralprogenitorcells |