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The translational importance of establishing biomarkers of human spinal cord injury
The evaluation of such novel therapies for acute spinal cord injury in clinical trials is extremely challenging. Our current dependence upon the clinical assessment of neurologic impairment renders many acute SCI patients ineligible for trials because they are not examinable. Furthermore, the diffic...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399708/ https://www.ncbi.nlm.nih.gov/pubmed/28469645 http://dx.doi.org/10.4103/1673-5374.202933 |
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author | Elizei, Sanam Salimi Kwon, Brian K. |
author_facet | Elizei, Sanam Salimi Kwon, Brian K. |
author_sort | Elizei, Sanam Salimi |
collection | PubMed |
description | The evaluation of such novel therapies for acute spinal cord injury in clinical trials is extremely challenging. Our current dependence upon the clinical assessment of neurologic impairment renders many acute SCI patients ineligible for trials because they are not examinable. Furthermore, the difficulty in predicting neurologic recovery based on the early clinical assessment forces investigators to recruit large cohorts to have sufficient power. Biomarkers that objectively classify injury severity and better predict neurologic outcome would be valuable tools for translational research. As such, the objective of the present review was to describe some of the translational challenges in acute spinal cord injury research and examine the potential utility of neurochemical biomarkers found within cerebrospinal fluid and blood. We focus on published efforts to establish biological markers for accurately classifying injury severity and precisely predict neurological outcome. |
format | Online Article Text |
id | pubmed-5399708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-53997082017-05-03 The translational importance of establishing biomarkers of human spinal cord injury Elizei, Sanam Salimi Kwon, Brian K. Neural Regen Res Invited Review The evaluation of such novel therapies for acute spinal cord injury in clinical trials is extremely challenging. Our current dependence upon the clinical assessment of neurologic impairment renders many acute SCI patients ineligible for trials because they are not examinable. Furthermore, the difficulty in predicting neurologic recovery based on the early clinical assessment forces investigators to recruit large cohorts to have sufficient power. Biomarkers that objectively classify injury severity and better predict neurologic outcome would be valuable tools for translational research. As such, the objective of the present review was to describe some of the translational challenges in acute spinal cord injury research and examine the potential utility of neurochemical biomarkers found within cerebrospinal fluid and blood. We focus on published efforts to establish biological markers for accurately classifying injury severity and precisely predict neurological outcome. Medknow Publications & Media Pvt Ltd 2017-03 /pmc/articles/PMC5399708/ /pubmed/28469645 http://dx.doi.org/10.4103/1673-5374.202933 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Invited Review Elizei, Sanam Salimi Kwon, Brian K. The translational importance of establishing biomarkers of human spinal cord injury |
title | The translational importance of establishing biomarkers of human spinal cord injury |
title_full | The translational importance of establishing biomarkers of human spinal cord injury |
title_fullStr | The translational importance of establishing biomarkers of human spinal cord injury |
title_full_unstemmed | The translational importance of establishing biomarkers of human spinal cord injury |
title_short | The translational importance of establishing biomarkers of human spinal cord injury |
title_sort | translational importance of establishing biomarkers of human spinal cord injury |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399708/ https://www.ncbi.nlm.nih.gov/pubmed/28469645 http://dx.doi.org/10.4103/1673-5374.202933 |
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