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Modulation of neuronal dynamic range using two different adaptation mechanisms

The capability of neurons to discriminate between intensity of external stimulus is measured by its dynamic range. A larger dynamic range indicates a greater probability of neuronal survival. In this study, the potential roles of adaptation mechanisms (ion currents) in modulating neuronal dynamic ra...

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Autores principales: Wang, Lei, Wang, Ye, Fu, Wen-long, Cao, Li-hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399723/
https://www.ncbi.nlm.nih.gov/pubmed/28469660
http://dx.doi.org/10.4103/1673-5374.202931
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author Wang, Lei
Wang, Ye
Fu, Wen-long
Cao, Li-hong
author_facet Wang, Lei
Wang, Ye
Fu, Wen-long
Cao, Li-hong
author_sort Wang, Lei
collection PubMed
description The capability of neurons to discriminate between intensity of external stimulus is measured by its dynamic range. A larger dynamic range indicates a greater probability of neuronal survival. In this study, the potential roles of adaptation mechanisms (ion currents) in modulating neuronal dynamic range were numerically investigated. Based on the adaptive exponential integrate-and-fire model, which includes two different adaptation mechanisms, i.e. subthreshold and suprathreshold (spike-triggered) adaptation, our results reveal that the two adaptation mechanisms exhibit rather different roles in regulating neuronal dynamic range. Specifically, subthreshold adaptation acts as a negative factor that observably decreases the neuronal dynamic range, while suprathreshold adaptation has little influence on the neuronal dynamic range. Moreover, when stochastic noise was introduced into the adaptation mechanisms, the dynamic range was apparently enhanced, regardless of what state the neuron was in, e.g. adaptive or non-adaptive. Our model results suggested that the neuronal dynamic range can be differentially modulated by different adaptation mechanisms. Additionally, noise was a non-ignorable factor, which could effectively modulate the neuronal dynamic range.
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spelling pubmed-53997232017-05-03 Modulation of neuronal dynamic range using two different adaptation mechanisms Wang, Lei Wang, Ye Fu, Wen-long Cao, Li-hong Neural Regen Res Research Article The capability of neurons to discriminate between intensity of external stimulus is measured by its dynamic range. A larger dynamic range indicates a greater probability of neuronal survival. In this study, the potential roles of adaptation mechanisms (ion currents) in modulating neuronal dynamic range were numerically investigated. Based on the adaptive exponential integrate-and-fire model, which includes two different adaptation mechanisms, i.e. subthreshold and suprathreshold (spike-triggered) adaptation, our results reveal that the two adaptation mechanisms exhibit rather different roles in regulating neuronal dynamic range. Specifically, subthreshold adaptation acts as a negative factor that observably decreases the neuronal dynamic range, while suprathreshold adaptation has little influence on the neuronal dynamic range. Moreover, when stochastic noise was introduced into the adaptation mechanisms, the dynamic range was apparently enhanced, regardless of what state the neuron was in, e.g. adaptive or non-adaptive. Our model results suggested that the neuronal dynamic range can be differentially modulated by different adaptation mechanisms. Additionally, noise was a non-ignorable factor, which could effectively modulate the neuronal dynamic range. Medknow Publications & Media Pvt Ltd 2017-03 /pmc/articles/PMC5399723/ /pubmed/28469660 http://dx.doi.org/10.4103/1673-5374.202931 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Wang, Lei
Wang, Ye
Fu, Wen-long
Cao, Li-hong
Modulation of neuronal dynamic range using two different adaptation mechanisms
title Modulation of neuronal dynamic range using two different adaptation mechanisms
title_full Modulation of neuronal dynamic range using two different adaptation mechanisms
title_fullStr Modulation of neuronal dynamic range using two different adaptation mechanisms
title_full_unstemmed Modulation of neuronal dynamic range using two different adaptation mechanisms
title_short Modulation of neuronal dynamic range using two different adaptation mechanisms
title_sort modulation of neuronal dynamic range using two different adaptation mechanisms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399723/
https://www.ncbi.nlm.nih.gov/pubmed/28469660
http://dx.doi.org/10.4103/1673-5374.202931
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