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Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

Mycolactone is the exotoxin virulence factor produced by Mycobacterium ulcerans, the pathogen responsible for Buruli ulcer. The skin lesions and immunosuppression that are characteristic of this disease result from the action of mycolactone, which targets the Sec61 complex and inhibits the co-transl...

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Detalles Bibliográficos
Autores principales:	McKenna, Michael, Simmonds, Rachel E., High, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399781/ https://www.ncbi.nlm.nih.gov/pubmed/28219954 http://dx.doi.org/10.1242/jcs.198655

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