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High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population
Chronic wasting disease (CWD) is a prion disease found in deer, elk and moose in North America and since recently, wild reindeer in Norway. Caribou are at-risk to encounter CWD in areas such as Alberta, Canada, where the disease spreads toward caribou habitats. CWD susceptibility is modulated by spe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399904/ https://www.ncbi.nlm.nih.gov/pubmed/28350512 http://dx.doi.org/10.1080/19336896.2017.1300741 |
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author | Cheng, Yo Ching Musiani, Marco Cavedon, Maria Gilch, Sabine |
author_facet | Cheng, Yo Ching Musiani, Marco Cavedon, Maria Gilch, Sabine |
author_sort | Cheng, Yo Ching |
collection | PubMed |
description | Chronic wasting disease (CWD) is a prion disease found in deer, elk and moose in North America and since recently, wild reindeer in Norway. Caribou are at-risk to encounter CWD in areas such as Alberta, Canada, where the disease spreads toward caribou habitats. CWD susceptibility is modulated by species-specific polymorphisms in the prion protein gene (Prnp). We sequenced Prnp of woodland caribou from 9 Albertan populations. In one population (Chinchaga) a significantly higher frequency of the 138N allele linked to reduced CWD susceptibility was observed. These data are relevant for developing CWD management strategies including conservation of threatened caribou populations. |
format | Online Article Text |
id | pubmed-5399904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-53999042017-04-27 High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population Cheng, Yo Ching Musiani, Marco Cavedon, Maria Gilch, Sabine Prion Short Communications Chronic wasting disease (CWD) is a prion disease found in deer, elk and moose in North America and since recently, wild reindeer in Norway. Caribou are at-risk to encounter CWD in areas such as Alberta, Canada, where the disease spreads toward caribou habitats. CWD susceptibility is modulated by species-specific polymorphisms in the prion protein gene (Prnp). We sequenced Prnp of woodland caribou from 9 Albertan populations. In one population (Chinchaga) a significantly higher frequency of the 138N allele linked to reduced CWD susceptibility was observed. These data are relevant for developing CWD management strategies including conservation of threatened caribou populations. Taylor & Francis 2017-03-28 /pmc/articles/PMC5399904/ /pubmed/28350512 http://dx.doi.org/10.1080/19336896.2017.1300741 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Short Communications Cheng, Yo Ching Musiani, Marco Cavedon, Maria Gilch, Sabine High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population |
title | High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population |
title_full | High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population |
title_fullStr | High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population |
title_full_unstemmed | High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population |
title_short | High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population |
title_sort | high prevalence of prion protein genotype associated with resistance to chronic wasting disease in one alberta woodland caribou population |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399904/ https://www.ncbi.nlm.nih.gov/pubmed/28350512 http://dx.doi.org/10.1080/19336896.2017.1300741 |
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