Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma

Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location‐ and dose‐dependent. A NO delivery platform that directly targets the resistance‐generating region of the conventional outflow pathway and locally liberates a controlled...

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Detalles Bibliográficos
Autores principales: Chandrawati, Rona, Chang, Jason Y. H., Reina‐Torres, Ester, Jumeaux, Coline, Sherwood, Joseph M., Stamer, W. Daniel, Zelikin, Alexander N., Overby, Darryl R., Stevens, Molly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400071/
https://www.ncbi.nlm.nih.gov/pubmed/28221702
http://dx.doi.org/10.1002/adma.201604932
Descripción
Sumario:Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location‐ and dose‐dependent. A NO delivery platform that directly targets the resistance‐generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model. [Image: see text]

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