Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma

Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location‐ and dose‐dependent. A NO delivery platform that directly targets the resistance‐generating region of the conventional outflow pathway and locally liberates a controlled...

Descripción completa

Detalles Bibliográficos
Autores principales: Chandrawati, Rona, Chang, Jason Y. H., Reina‐Torres, Ester, Jumeaux, Coline, Sherwood, Joseph M., Stamer, W. Daniel, Zelikin, Alexander N., Overby, Darryl R., Stevens, Molly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400071/
https://www.ncbi.nlm.nih.gov/pubmed/28221702
http://dx.doi.org/10.1002/adma.201604932
_version_ 1783230757421973504
author Chandrawati, Rona
Chang, Jason Y. H.
Reina‐Torres, Ester
Jumeaux, Coline
Sherwood, Joseph M.
Stamer, W. Daniel
Zelikin, Alexander N.
Overby, Darryl R.
Stevens, Molly M.
author_facet Chandrawati, Rona
Chang, Jason Y. H.
Reina‐Torres, Ester
Jumeaux, Coline
Sherwood, Joseph M.
Stamer, W. Daniel
Zelikin, Alexander N.
Overby, Darryl R.
Stevens, Molly M.
author_sort Chandrawati, Rona
collection PubMed
description Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location‐ and dose‐dependent. A NO delivery platform that directly targets the resistance‐generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model. [Image: see text]
format Online
Article
Text
id pubmed-5400071
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-54000712017-04-21 Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma Chandrawati, Rona Chang, Jason Y. H. Reina‐Torres, Ester Jumeaux, Coline Sherwood, Joseph M. Stamer, W. Daniel Zelikin, Alexander N. Overby, Darryl R. Stevens, Molly M. Adv Mater Communications Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location‐ and dose‐dependent. A NO delivery platform that directly targets the resistance‐generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model. [Image: see text] John Wiley and Sons Inc. 2017-02-21 2017-04-25 /pmc/articles/PMC5400071/ /pubmed/28221702 http://dx.doi.org/10.1002/adma.201604932 Text en © 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Chandrawati, Rona
Chang, Jason Y. H.
Reina‐Torres, Ester
Jumeaux, Coline
Sherwood, Joseph M.
Stamer, W. Daniel
Zelikin, Alexander N.
Overby, Darryl R.
Stevens, Molly M.
Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma
title Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma
title_full Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma
title_fullStr Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma
title_full_unstemmed Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma
title_short Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma
title_sort localized and controlled delivery of nitric oxide to the conventional outflow pathway via enzyme biocatalysis: toward therapy for glaucoma
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400071/
https://www.ncbi.nlm.nih.gov/pubmed/28221702
http://dx.doi.org/10.1002/adma.201604932
work_keys_str_mv AT chandrawatirona localizedandcontrolleddeliveryofnitricoxidetotheconventionaloutflowpathwayviaenzymebiocatalysistowardtherapyforglaucoma
AT changjasonyh localizedandcontrolleddeliveryofnitricoxidetotheconventionaloutflowpathwayviaenzymebiocatalysistowardtherapyforglaucoma
AT reinatorresester localizedandcontrolleddeliveryofnitricoxidetotheconventionaloutflowpathwayviaenzymebiocatalysistowardtherapyforglaucoma
AT jumeauxcoline localizedandcontrolleddeliveryofnitricoxidetotheconventionaloutflowpathwayviaenzymebiocatalysistowardtherapyforglaucoma
AT sherwoodjosephm localizedandcontrolleddeliveryofnitricoxidetotheconventionaloutflowpathwayviaenzymebiocatalysistowardtherapyforglaucoma
AT stamerwdaniel localizedandcontrolleddeliveryofnitricoxidetotheconventionaloutflowpathwayviaenzymebiocatalysistowardtherapyforglaucoma
AT zelikinalexandern localizedandcontrolleddeliveryofnitricoxidetotheconventionaloutflowpathwayviaenzymebiocatalysistowardtherapyforglaucoma
AT overbydarrylr localizedandcontrolleddeliveryofnitricoxidetotheconventionaloutflowpathwayviaenzymebiocatalysistowardtherapyforglaucoma
AT stevensmollym localizedandcontrolleddeliveryofnitricoxidetotheconventionaloutflowpathwayviaenzymebiocatalysistowardtherapyforglaucoma

Ejemplares similares