Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population

Background: The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%–10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Objectives: To undertake a genome-wide association study (GWAS) to id...

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Detalles Bibliográficos
Autores principales: Carr, Daniel F., Bourgeois, Stephane, Chaponda, Mas, Takeshita, Louise Y., Morris, Andrew P., Castro, Elena M. Cornejo, Alfirevic, Ana, Jones, Andrew R., Rigden, Daniel J., Haldenby, Sam, Khoo, Saye, Lalloo, David G., Heyderman, Robert S., Dandara, Collet, Kampira, Elizabeth, van Oosterhout, Joep J., Ssali, Francis, Munderi, Paula, Novelli, Giuseppe, Borgiani, Paola, Nelson, Matthew R., Holden, Arthur, Deloukas, Panos, Pirmohamed, Munir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400091/
https://www.ncbi.nlm.nih.gov/pubmed/28062682
http://dx.doi.org/10.1093/jac/dkw545

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