NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity

Animal studies have shown that the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus can activate the thiazide-sensitive NaCl cotransporter (NCC). A common side effect of CNIs is hypertension. Renal salt transporters such as NCC are excreted in urinary extracellular vesicles (uEVs) after int...

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Detalles Bibliográficos
Autores principales: Tutakhel, Omar A. Z., Moes, Arthur D., Valdez-Flores, Marco A., Kortenoeven, Marleen L. A., Vrie, Mathijs v. D., Jeleń, Sabina, Fenton, Robert A., Zietse, Robert, Hoenderop, Joost G. J., Hoorn, Ewout J., Hilbrands, Luuk, Bindels, René J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400280/
https://www.ncbi.nlm.nih.gov/pubmed/28430812
http://dx.doi.org/10.1371/journal.pone.0176220

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