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(18)F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series
Because Q fever is mostly diagnosed serologically, localizing a persistent focus of Coxiella burnetii infection can be challenging. (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) could be an interesting tool in this context. We performed a retrospective...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400310/ https://www.ncbi.nlm.nih.gov/pubmed/27559944 http://dx.doi.org/10.1097/MD.0000000000004287 |
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author | Eldin, Carole Melenotte, Cléa Million, Matthieu Cammilleri, Serge Sotto, Albert Elsendoorn, Antoine Thuny, Franck Lepidi, Hubert Roblot, France Weitten, Thierry Assaad, Souad Bouaziz, Anissa Chapuzet, Claire Gras, Guillaume Labussiere, Anne-Sophie Landais, Cécile Longuet, Pascale Masseau, Agathe Mundler, Olivier Raoult, Didier |
author_facet | Eldin, Carole Melenotte, Cléa Million, Matthieu Cammilleri, Serge Sotto, Albert Elsendoorn, Antoine Thuny, Franck Lepidi, Hubert Roblot, France Weitten, Thierry Assaad, Souad Bouaziz, Anissa Chapuzet, Claire Gras, Guillaume Labussiere, Anne-Sophie Landais, Cécile Longuet, Pascale Masseau, Agathe Mundler, Olivier Raoult, Didier |
author_sort | Eldin, Carole |
collection | PubMed |
description | Because Q fever is mostly diagnosed serologically, localizing a persistent focus of Coxiella burnetii infection can be challenging. (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) could be an interesting tool in this context. We performed a retrospective study on patients diagnosed with C burnetii infection, who had undergone (18)F-FDG PET/CT between 2009 and 2015. When positive (18)F-FDG PET/CT results were obtained, we tried to determine if it changed the previous diagnosis by discovering or confirming a suspected focus of C burnetii infection. One hundred sixty-seven patients benefited from (18)F-FDG PET/CT. The most frequent clinical subgroup before (18)F-FDG PET/CT was patients with no identified focus of infection, despite high IgG1 serological titers (34%). For 59% (n = 99) of patients, a hypermetabolic focus was identified. For 62 patients (62.6%), the positive (18)F-FDG PET/CT allowed the diagnosis to be changed. For 24 of them, (38.7%), a previously unsuspected focus of infection was discovered. Forty-two (42%) positive patients had more than 1 hypermetabolic focus. We observed 21 valvular foci, 34 vascular foci, and a high proportion of osteoarticular localizations (n = 21). We also observed lymphadenitis (n = 27), bone marrow hypermetabolism (n = 11), and 9 pulmonary localizations. We confirmed that(18)F-FDG PET/CT is a central tool in the diagnosis of C burnetii focalized persistent infection. We proposed new diagnostic scores for 2 main clinical entities identified using (18)F-FDG PET/CT: osteoarticular persistent infections and lymphadenitis. |
format | Online Article Text |
id | pubmed-5400310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-54003102017-04-27 (18)F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series Eldin, Carole Melenotte, Cléa Million, Matthieu Cammilleri, Serge Sotto, Albert Elsendoorn, Antoine Thuny, Franck Lepidi, Hubert Roblot, France Weitten, Thierry Assaad, Souad Bouaziz, Anissa Chapuzet, Claire Gras, Guillaume Labussiere, Anne-Sophie Landais, Cécile Longuet, Pascale Masseau, Agathe Mundler, Olivier Raoult, Didier Medicine (Baltimore) 4900 Because Q fever is mostly diagnosed serologically, localizing a persistent focus of Coxiella burnetii infection can be challenging. (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) could be an interesting tool in this context. We performed a retrospective study on patients diagnosed with C burnetii infection, who had undergone (18)F-FDG PET/CT between 2009 and 2015. When positive (18)F-FDG PET/CT results were obtained, we tried to determine if it changed the previous diagnosis by discovering or confirming a suspected focus of C burnetii infection. One hundred sixty-seven patients benefited from (18)F-FDG PET/CT. The most frequent clinical subgroup before (18)F-FDG PET/CT was patients with no identified focus of infection, despite high IgG1 serological titers (34%). For 59% (n = 99) of patients, a hypermetabolic focus was identified. For 62 patients (62.6%), the positive (18)F-FDG PET/CT allowed the diagnosis to be changed. For 24 of them, (38.7%), a previously unsuspected focus of infection was discovered. Forty-two (42%) positive patients had more than 1 hypermetabolic focus. We observed 21 valvular foci, 34 vascular foci, and a high proportion of osteoarticular localizations (n = 21). We also observed lymphadenitis (n = 27), bone marrow hypermetabolism (n = 11), and 9 pulmonary localizations. We confirmed that(18)F-FDG PET/CT is a central tool in the diagnosis of C burnetii focalized persistent infection. We proposed new diagnostic scores for 2 main clinical entities identified using (18)F-FDG PET/CT: osteoarticular persistent infections and lymphadenitis. Wolters Kluwer Health 2016-08-26 /pmc/articles/PMC5400310/ /pubmed/27559944 http://dx.doi.org/10.1097/MD.0000000000004287 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 4900 Eldin, Carole Melenotte, Cléa Million, Matthieu Cammilleri, Serge Sotto, Albert Elsendoorn, Antoine Thuny, Franck Lepidi, Hubert Roblot, France Weitten, Thierry Assaad, Souad Bouaziz, Anissa Chapuzet, Claire Gras, Guillaume Labussiere, Anne-Sophie Landais, Cécile Longuet, Pascale Masseau, Agathe Mundler, Olivier Raoult, Didier (18)F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series |
title | (18)F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series |
title_full | (18)F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series |
title_fullStr | (18)F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series |
title_full_unstemmed | (18)F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series |
title_short | (18)F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series |
title_sort | (18)f-fdg pet/ct as a central tool in the shift from chronic q fever to coxiella burnetii persistent focalized infection: a consecutive case series |
topic | 4900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400310/ https://www.ncbi.nlm.nih.gov/pubmed/27559944 http://dx.doi.org/10.1097/MD.0000000000004287 |
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