Cargando…
Rfam: annotating non-coding RNAs in complete genomes
Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRN...
Autores principales: | , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC540035/ https://www.ncbi.nlm.nih.gov/pubmed/15608160 http://dx.doi.org/10.1093/nar/gki081 |
_version_ | 1782122108664414208 |
---|---|
author | Griffiths-Jones, Sam Moxon, Simon Marshall, Mhairi Khanna, Ajay Eddy, Sean R. Bateman, Alex |
author_facet | Griffiths-Jones, Sam Moxon, Simon Marshall, Mhairi Khanna, Ajay Eddy, Sean R. Bateman, Alex |
author_sort | Griffiths-Jones, Sam |
collection | PubMed |
description | Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/. |
format | Text |
id | pubmed-540035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-5400352005-01-04 Rfam: annotating non-coding RNAs in complete genomes Griffiths-Jones, Sam Moxon, Simon Marshall, Mhairi Khanna, Ajay Eddy, Sean R. Bateman, Alex Nucleic Acids Res Articles Rfam is a comprehensive collection of non-coding RNA (ncRNA) families, represented by multiple sequence alignments and profile stochastic context-free grammars. Rfam aims to facilitate the identification and classification of new members of known sequence families, and distributes annotation of ncRNAs in over 200 complete genome sequences. The data provide the first glimpses of conservation of multiple ncRNA families across a wide taxonomic range. A small number of large families are essential in all three kingdoms of life, with large numbers of smaller families specific to certain taxa. Recent improvements in the database are discussed, together with challenges for the future. Rfam is available on the Web at http://www.sanger.ac.uk/Software/Rfam/ and http://rfam.wustl.edu/. Oxford University Press 2005-01-01 2004-12-17 /pmc/articles/PMC540035/ /pubmed/15608160 http://dx.doi.org/10.1093/nar/gki081 Text en Copyright © 2005 Oxford University Press |
spellingShingle | Articles Griffiths-Jones, Sam Moxon, Simon Marshall, Mhairi Khanna, Ajay Eddy, Sean R. Bateman, Alex Rfam: annotating non-coding RNAs in complete genomes |
title | Rfam: annotating non-coding RNAs in complete genomes |
title_full | Rfam: annotating non-coding RNAs in complete genomes |
title_fullStr | Rfam: annotating non-coding RNAs in complete genomes |
title_full_unstemmed | Rfam: annotating non-coding RNAs in complete genomes |
title_short | Rfam: annotating non-coding RNAs in complete genomes |
title_sort | rfam: annotating non-coding rnas in complete genomes |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC540035/ https://www.ncbi.nlm.nih.gov/pubmed/15608160 http://dx.doi.org/10.1093/nar/gki081 |
work_keys_str_mv | AT griffithsjonessam rfamannotatingnoncodingrnasincompletegenomes AT moxonsimon rfamannotatingnoncodingrnasincompletegenomes AT marshallmhairi rfamannotatingnoncodingrnasincompletegenomes AT khannaajay rfamannotatingnoncodingrnasincompletegenomes AT eddyseanr rfamannotatingnoncodingrnasincompletegenomes AT batemanalex rfamannotatingnoncodingrnasincompletegenomes |