Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia

Tibetans are well adapted to the hypoxic environments at high altitude, yet the molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses of EPAS1, a gene encoding hypoxia inducible factor 2α (HIF-2α) with the strongest signal of selection in p...

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Detalles Bibliográficos
Autores principales: Peng, Yi, Cui, Chaoying, He, Yaoxi, Ouzhuluobu, Zhang, Hui, Yang, Deying, Zhang, Qu, Bianbazhuoma, Yang, Lixin, He, Yibo, Xiang, Kun, Zhang, Xiaoming, Bhandari, Sushil, Shi, Peng, Yangla, Dejiquzong, Baimakangzhuo, Duojizhuoma, Pan, Yongyue, Cirenyangji, Baimayangji, Gonggalanzi, Bai, Caijuan, Bianba, Basang, Ciwangsangbu, Xu, Shuhua, Chen, Hua, Liu, Shiming, Wu, Tianyi, Qi, Xuebin, Su, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400376/
https://www.ncbi.nlm.nih.gov/pubmed/28096303
http://dx.doi.org/10.1093/molbev/msw280

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