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Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase

A leading intellectual challenge in evolutionary genetics is to identify the specific phenotypes that drive adaptation. Enzymes offer a particularly promising opportunity to pursue this question, because many enzymes’ contributions to organismal fitness depend on a comparatively small number of expe...

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Detalles Bibliográficos
Autores principales:	Knies, Jennifer L., Cai, Fei, Weinreich, Daniel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Discoveries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400381/ https://www.ncbi.nlm.nih.gov/pubmed/28087769 http://dx.doi.org/10.1093/molbev/msx053

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